Atorvastatin exerts anti‑nociceptive activity and decreases serum levels of high‑sensitivity C‑reactive protein and tumor necrosis factor‑α in a rat endometriosis model

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dc.contributor.authorSimsek, Yavuz
dc.contributor.authorGul, Mehmet
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorOzerol, Ibrahim Halil
dc.contributor.authorOzerol, Elif
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2020-06-25T18:08:04Z
dc.date.available2020-06-25T18:08:04Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionParlakpinar, Hakan/0000-0001-9497-3468
dc.description.abstractPurpose The purpose of this study was to examine the effects of atorvastatin in the treatment of experimental endometriosis. Methods Endometriosis was induced in 24 female rats. 4 weeks after the procedure dimensions of the foci were recorded. Rats were divided into three groups: in Group 1 (n = 8), a daily dose of 10 mg/kg atorvastatin was given for 14 days. In the second group (n = 8), a single dose of 1 mg/kg leuprolide acetate was injected intraperitoneally. The rats in Group 3 (n = 8) were received 1 mg/kg i.p. 0.9 % NaCl. At the end of the treatment, laparotomy was performed, and the dimensions of the endometriotic foci were recorded. Biochemical, histopathological and immunohistochemical studies were performed and nociception was compared in groups. Results Atorvastatin treatment exhibited significant analgesic activity in hot plate model (P = 0.022). The serum hs-CRP and tumor necrosis TNF-alpha levels were similar between the Group 2 and Group 3 (P > 0.05); however atorvastatin caused significant decrease in both serum markers. The histological and immunohistochemical scores were also found to be markedly lower in Group 1 and Group 2 (P < 0.05). Conclusion Atorvastatin treatment may have a therapeutic potential in the treatment of endometriosis through its anti-inflammatory and anti-nociceptive properties.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00404-014-3295-4
dc.identifier.endpage1006en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue5en_US
dc.identifier.pmid24913463
dc.identifier.scopus2-s2.0-84927566258
dc.identifier.scopusqualityQ2
dc.identifier.startpage999en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-014-3295-4
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5718
dc.identifier.volume290en_US
dc.identifier.wosWOS:000343651400028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Gynecology And Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStatinsen_US
dc.subjectEndometriosisen_US
dc.subjectPain controlen_US
dc.subjectInflammationen_US
dc.titleAtorvastatin exerts anti‑nociceptive activity and decreases serum levels of high‑sensitivity C‑reactive protein and tumor necrosis factor‑α in a rat endometriosis modelen_US
dc.typeArticle

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