Vitex Agnus-Castus L. Nanoparticles: Preparation, Characterization and Assessment of Antimicrobial and Anticancer Activity

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dc.authoridALUC, YASAR/0000-0002-2650-2290
dc.authoridEkici, Seda/0000-0002-7982-5261
dc.authoridCerci, Nebahat Aytuna/0000-0002-7864-7213
dc.authoridEkici, Husamettin/0000-0001-6403-737X
dc.contributor.authorEkici, Seda
dc.contributor.authorBozkaya, Esra
dc.contributor.authorBozkaya, Ogun
dc.contributor.authorCerci, Nebahat Aytuna
dc.contributor.authorAluc, Yasar
dc.contributor.authorEkici, Husamettin
dc.date.accessioned2025-01-21T16:55:54Z
dc.date.available2025-01-21T16:55:54Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study was aimed to synthesise antimicrobial and therapeutic silver nanoparticles (AgNPs) by green synthesis method using Vitex agnus-castus L. (VAC) seed extract. The synthesised VAC seed extract coated AgNPs were characterised by UV-Vis spectrometry, Zeta analysis and FT-IR spectrometry. The antifungal, antimicrobial, cytotoxicity by MTT assay, and anticarcinogenic activities on HeLa cells line were investigated. VACAgNPs exhibited high antimicrobial activity against S. aureus with a zone diameter of 11.3 +/- 0.6 mm. In addition, the cytotoxicity of VAC-AgNPs was evaluated using the L929 fibroblast cell line and the HeLa cells line, with AgNPs applied at six different concentrations. At a concentration of 5.0 mM, viability was found to be 47.6%+/- 4.2% in L929 fibroblast cells and 39.6%+/- 7.9% in HeLa cells, suggesting a potential antiproliferative effect of VAC-AgNPs on HeLa cancer cells. The IC50 values of VAC-AgNPs against the HeLa cell line were calculated as 2.94 mu g/ml.
dc.identifier.doi10.1002/slct.202302102
dc.identifier.issn2365-6549
dc.identifier.issue32
dc.identifier.scopus2-s2.0-85168676355
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202302102
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25867
dc.identifier.volume8
dc.identifier.wosWOS:001062319100007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAnticancer; green synthesis; HeLa cells; silver nanoparticles; vitex agnus-castus
dc.titleVitex Agnus-Castus L. Nanoparticles: Preparation, Characterization and Assessment of Antimicrobial and Anticancer Activity
dc.typeArticle

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