Genetics and some aging-related mechanisms

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dc.contributor.authorÇakir S.
dc.date.accessioned2020-06-25T15:13:11Z
dc.date.available2020-06-25T15:13:11Z
dc.date.issued2000
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAging can be defined as the time-dependent decline of physiological functions of an organism. Aging, a multifactorial process composed of both genetic and environmental components, is a highly complex biologic phenomenon of great importance. The details of the mechanisms leading to aging are not yet known. All changes in the process of aging have a cellular basis, and perhaps aging should be studied, fundamantally, at the cellular level under defined and controlled environmental conditions. Some genetic approaches have promise for the understanding of this multifactorial process. In this review, some causal hypotheses related to oxidative damage, caloric restriction, mitochondrial mutations, protein elongation factor (EF-1), stress proteins (Hsp70), altered gene regulation and telomere loss are discussed to clarify the mechanisms of aging. Aging must be considered as parts comprising a whole, it must be understood as the sum of its parts. Although there are some experimental results supporting these hypotheses, there is still much to learn about the genetics of aging.en_US
dc.identifier.citationÇakır, Ş. (2000). Genetics and some aging-related mechanisms. Turkish Journal of Zoology, 24(2), 183 - 190.en_US
dc.identifier.endpage190en_US
dc.identifier.issn13000179
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0040954613
dc.identifier.scopusqualityQ2
dc.identifier.startpage183en_US
dc.identifier.trdizinid26558
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1637
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Zoology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgingen_US
dc.subjectAging-related mechanismsen_US
dc.subjectGeneticsen_US
dc.titleGenetics and some aging-related mechanismsen_US
dc.typeArticle

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