Corneal thickness and endothelial changes in long-term hydroxychloroquine use

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dc.contributor.authorOğurel, Tevfik
dc.contributor.authorÖzer, Murat Atabey
dc.contributor.authorAkbulut, Yaprak
dc.contributor.authorGökçınar, Nesrin Büyüktortop
dc.contributor.authorOnaran, Zafer
dc.contributor.authorÜreten, Kemal
dc.date.accessioned2020-06-25T18:34:04Z
dc.date.available2020-06-25T18:34:04Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.descriptionGokcinar, Nesrin Buyuktortop/0000-0001-7795-5188
dc.description.abstractObjective: To determine possible associations between long-term HCQ use and corneal changes in patients who used HCQ for at least 3 years. Materials and methods: The study included 62 healthy controls and 62 consecutive patients who used HCQ for the treatment of rheumatologic disease and were referred to the ophthalmology department between August 2018 and November 2018 for HCQ retinal toxicity screening. Central corneal thickness (CCT), corneal endothelial cell density (ECD), the coefficient of variation (CV) of cell size, and the percentage of hexagonal cells (HEX%) were measured to evaluate changes in the cornea. Results: The mean age of the patient group and control group was 50.10 +/- 10.91 and 50.53 +/- 10.67 years, respectively. The mean ECD was 2742 +/- 347 (cells/mm(2)) in the patient group and 2875 +/- 188 cells/mm(2) in the control group. There was a significant difference between groups (p = 0.01). The mean CCT was 567.05 +/- 32.35 mu m in the patient group and 540.15 +/- 38.50 mu m in the control group. CCT was significantly higher in the patient group compared with control group (p < 0.001). There was no significant difference between groups in terms of mean CV and HEX values (p > 0.05). Conclusions: Patients using long-term HCQ demonstrated lower ECD and higher CCT than the control group. However, the CV of cell sizes and the HEX % values were not significantly different from the controls.en_US
dc.identifier.citationclosedAccess
dc.identifier.doi10.1080/15569527.2019.1608228
dc.identifier.endpage289en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue3en_US
dc.identifier.pmid31010339
dc.identifier.scopus2-s2.0-85066015918
dc.identifier.scopusqualityQ3
dc.identifier.startpage286en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2019.1608228
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7785
dc.identifier.volume38en_US
dc.identifier.wosWOS:000469731800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous And Ocular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHydroxychloroquineen_US
dc.subjectcorneal thicknessen_US
dc.subjectendothelial cell densityen_US
dc.titleCorneal thickness and endothelial changes in long-term hydroxychloroquine useen_US
dc.typeArticle

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