Inducible nitric oxide synthase (iNOS) in sinonasal polyp pathogenesis

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dc.contributor.authorMuluk, N. Bayar
dc.contributor.authorArikan, O. K.
dc.contributor.authorAtasoy, P.
dc.contributor.authorKilic, R.
dc.contributor.authorYalcinozan, E. Tuna
dc.date.accessioned2020-06-25T18:07:37Z
dc.date.available2020-06-25T18:07:37Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We investigated the role of inducible nitric oxide synthase (iNOS) in the pathogenesis of sinonasal polyps. Methods: Adult patients (21 men, 3 women) with nasal polyposis underwent functional endoscopic sinus surgery. Nine adults without polyps (6 men) who underwent septoplasty and/or rhinoplasty served as controls. Polyp specimens came from three regions: the maxillary sinus (10), ethmoid sinus (14), and nasal cavity (10). Control group samples (9) came from the inferior turbinate. Specimens were evaluated in eight mucosal layers for count and distribution of inflammatory cells and iNOS expression. An iNOS positivity index (PI) was determined for the epithelium (E), subepithelial layer of the lamina propria (SE), and deep paraglandular layer of the mucosa (D). Results: Polymorphonuclear cell (PMNC) % values of the ethmoid and maxillary sinus and overall ethmoid sinus PI were significantly higher in the polyp group. Patients with longer polyp duration, D-perivascular (D-pv), and a higher Brinkmann index had decreased ethmoid sinus D Pis. However, in older patients and patients with longer polyp duration, perivascular PIs increased in maxillary sinus SE and D, respectively. Furthermore, as PMNC % and iNOS-PMNC PI increased, SE_glandular and epithelial_apical iNOS values decreased. In the ethmoid and maxillary sinuses, iNOS_D_endothelial values increased but decreased in the nasal cavity. Conclusions: iNOS may play a role in sinonasal polyp pathogenesis, especially in mucosal SE and D layers. Increased vascular permeability, stromal edema, inflammatory cell migration into the stroma of the mucosa, and increased mucosal gland secretion may result in polyp formation.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Unit FundsKirikkale Universityen_US
dc.description.sponsorshipThis study was supported by Kirikkale University Scientific Research Projects Unit Funds.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage216en_US
dc.identifier.issn1781-782X
dc.identifier.issue3en_US
dc.identifier.pmid24273952
dc.identifier.scopus2-s2.0-84886862768
dc.identifier.scopusqualityQ3
dc.identifier.startpage207en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5624
dc.identifier.volume9en_US
dc.identifier.wosWOS:000326554400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoyal Belgian Soc Ear, Nose, Throat, Head & Neck Surgeryen_US
dc.relation.ispartofB-Ent
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSinonasal polypen_US
dc.subjectpathogenesisen_US
dc.subjectinducible nitric oxide synthase (iNOS)en_US
dc.subjectglandularen_US
dc.subjectendothelialen_US
dc.subjectiNOS positivity indexen_US
dc.titleInducible nitric oxide synthase (iNOS) in sinonasal polyp pathogenesisen_US
dc.typeArticle

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