Synthesis, structural characterization and myorelaxant activity of 4-naphthylhexahydroquinoline derivatives containing different ester groups
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Serbian Chemical Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The present study reports the synthesis, structural characterization and myorelaxant activity evaluation of a series of 16 novel 4-naphthylhexahydroquinoline derivatives. The compounds were achieved by one-pot microwave-assisted method via a modified Hantzsch reaction. The structures of the compounds were confirmed by various spectral methods, such as IR, 1D and 2D NMR techniques and mass analysis. X-Ray studies of compound 10 provided further evidence for the proposed structure. To evaluate their myorelaxant activities, the E-max and pD(2) values of the compounds and nifedipine were determined on isolated rabbit gastric fundus smooth muscle strips. The obtained results indicated that the introduction of long chain alkyl groups, such as the 2-methoxyethyl or 2-(methacryloyloxy)ethyl moiety, to the ester group led to the most active compounds.
Açıklama
Gunduz, Miyase Gozde/0000-0002-2287-9509; Bayram, Cem/0000-0001-8717-4668; SARIOGLU, YUSUF/0000-0002-9227-365X
Anahtar Kelimeler
1,4-dihydropyridine, synthesis, myorelaxant activity, crystal structure, structure elucidation
Kaynak
Journal Of The Serbian Chemical Society
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
81
Sayı
7
Künye
Gündüz, M.G., Albayrak, E., Isli, F., Fincan, G.S., Yıldırım, Ş., Şimşek, R., Şafak, C., Sarıoǧlu, Y., Yıldırım, S.Ö., & Butcher, R.J. (2016). Synthesis, structural characterization and myorelaxant activity of 4-naphthylhexahydroquinoline derivatives containing different ester groups. Journal of The Serbian Chemical Society, 81, 729-738.
