Synthesis, structural characterization and myorelaxant activity of 4-naphthylhexahydroquinoline derivatives containing different ester groups

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dc.contributor.authorGunduz, Miyase Gozde
dc.contributor.authorAlbayrak, Emine
dc.contributor.authorIsli, Fatma
dc.contributor.authorFincan, Gokce Sevim Ozturk
dc.contributor.authorYildirim, Seniz
dc.contributor.authorSimsek, Rahime
dc.contributor.authorButcher, Ray J.
dc.date.accessioned2020-06-25T18:22:32Z
dc.date.available2020-06-25T18:22:32Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionGunduz, Miyase Gozde/0000-0002-2287-9509; Bayram, Cem/0000-0001-8717-4668; SARIOGLU, YUSUF/0000-0002-9227-365X
dc.description.abstractThe present study reports the synthesis, structural characterization and myorelaxant activity evaluation of a series of 16 novel 4-naphthylhexahydroquinoline derivatives. The compounds were achieved by one-pot microwave-assisted method via a modified Hantzsch reaction. The structures of the compounds were confirmed by various spectral methods, such as IR, 1D and 2D NMR techniques and mass analysis. X-Ray studies of compound 10 provided further evidence for the proposed structure. To evaluate their myorelaxant activities, the E-max and pD(2) values of the compounds and nifedipine were determined on isolated rabbit gastric fundus smooth muscle strips. The obtained results indicated that the introduction of long chain alkyl groups, such as the 2-methoxyethyl or 2-(methacryloyloxy)ethyl moiety, to the ester group led to the most active compounds.en_US
dc.description.sponsorshipScientific Research Fund of Hacettepe University, TurkeyHacettepe University [013.D03.301.001]; NSF-MRI programNational Science Foundation (NSF)NSF - Office of the Director (OD) [CHE-0619278]en_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support provided by the Scientific Research Fund of Hacettepe University, Turkey through Project 013.D03.301.001.; RJB wishes to acknowledge the NSF-MRI program (grant CHE-0619278) for funds to purchase the diffractometer and the Howard University Nanoscience Facility for access to liquid nitrogen.en_US
dc.identifier.citationGündüz, M.G., Albayrak, E., Isli, F., Fincan, G.S., Yıldırım, Ş., Şimşek, R., Şafak, C., Sarıoǧlu, Y., Yıldırım, S.Ö., & Butcher, R.J. (2016). Synthesis, structural characterization and myorelaxant activity of 4-naphthylhexahydroquinoline derivatives containing different ester groups. Journal of The Serbian Chemical Society, 81, 729-738.en_US
dc.identifier.doi10.2298/JSC151206035G
dc.identifier.endpage738en_US
dc.identifier.issn0352-5139
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-84982698632
dc.identifier.scopusqualityQ3
dc.identifier.startpage729en_US
dc.identifier.urihttps://doi.org/10.2298/JSC151206035G
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6793
dc.identifier.volume81en_US
dc.identifier.wosWOS:000382175400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSerbian Chemical Socen_US
dc.relation.ispartofJournal Of The Serbian Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject1,4-dihydropyridineen_US
dc.subjectsynthesisen_US
dc.subjectmyorelaxant activityen_US
dc.subjectcrystal structureen_US
dc.subjectstructure elucidationen_US
dc.titleSynthesis, structural characterization and myorelaxant activity of 4-naphthylhexahydroquinoline derivatives containing different ester groupsen_US
dc.typeArticle

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