Effects of iron overload and exenatide on erythrocyte deformability in a rat model

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dc.contributor.authorKuşkonmaz, Şerife Mehlika
dc.contributor.authorKara, Halil
dc.contributor.authorÇomu, Faruk Metin
dc.contributor.authorKüçük, Ayşegül
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2020-06-25T18:12:34Z
dc.date.available2020-06-25T18:12:34Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063;
dc.description.abstractIron overload is known to affect erythrocyte membrane properties and erythrocyte shape. We hypothesized that iron overload which directly affects the erythrocyte morphology may also interfere with erythrocyte deformability (ED). Exenatide, a glucagon like peptide -1 (GLP-1) analogue used in the treatment of diabetes, is known to have beneficial pleiotropic effects on endothelial function and blood flow which are different from its glucose-lowering effects. In our study we aimed to test the effect of iron overload on ED in a rat model (1) and to evaluate the effect of exenatide on ED in the same model (2). For this purpose, the animals were randomly divided into three groups, each containing 6 rats. Rats in the control group (Group C) were given intraperitoneal injections of saline as placebo. The second group (Group Fe) was given intraperitoneal iron dextran (60 mg/kg/day) five days a week for 4 weeks to develop iron overload. The third group (Group Fe + E) received subcutaneous injections of 10 mcg exenatide (Byetta (R) Lilly Pharma) in two divided doses for 4 weeks in addition to iron dextran. We observed that ED index was significantly higher in Group Fe when compared to Group C and Group Fe+E (p <0.0001, p <0.0001). Administration of exenatide to the iron-loaded rats (Group Fe +E) led to a significant decrease in the deformability index (p < 0.017) when compared to Group Fe. Our study shows a decrease in ED with iron and beneficial effect of exenatide on ED in the iron-overloaded rat model (Fig. 1, Ref. 24). Text in PDF www.elis.sk.en_US
dc.identifier.citationKuskonmaz, S. M., Kara, H., Comu, F. M., Kucuk, A., & Arslan, M. (2015). Effects of iron overload and exenatide on erythrocyte deformability in a rat model. Bratislavske lekarske listy, 116(12), 751–753. https://doi.org/10.4149/bll_2015_147en_US
dc.identifier.doi10.4149/BLL_2015_147
dc.identifier.endpage753en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12en_US
dc.identifier.pmid26924147
dc.identifier.scopus2-s2.0-84973400104
dc.identifier.scopusqualityQ2
dc.identifier.startpage751en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_147
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5971
dc.identifier.volume116en_US
dc.identifier.wosWOS:000367280800012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectironen_US
dc.subjectexenatideen_US
dc.titleEffects of iron overload and exenatide on erythrocyte deformability in a rat modelen_US
dc.typeArticle

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