Comparison of the efficacy of propofol and metoclopramide in preventing postoperative nausea and vomiting after middle ear surgery

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dc.contributor.authorÜnal, Yusuf
dc.contributor.authorÖzsoylar, Özgür
dc.contributor.authorArslan, Mustafa
dc.contributor.authorSarıgüney, Damla
dc.contributor.authorAkçabay, Mehmet
dc.date.accessioned2020-06-25T17:48:26Z
dc.date.available2020-06-25T17:48:26Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractObjectives: To compare the administration of sub hypnotic dose of propofol with metoclopramide and placebo in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. Methods: This clinical research was performed in the Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey, between December 2004 and October 2005. Following approval by the hospital ethics committee, 60 adult patients scheduled for a middle ear operation were randomly assigned into 3 groups. The patients in group P received 0.5 mg.kg(-1) propofol; in group M, 0.2 mg.kg(-1) metoclopramide, and in group C, 0.9% saline solution. The number of patients suffering from nausea and vomiting at 0-4, 4-12, and 12-24 hours postoperatively, and additional use of antiemetics was recorded. Results: Comparison of the data showed that at 0-4th hours, the incidence of vomiting was 25% in group P, 40% in group M, and 75% in group C. The incidence rate of group P was significantly lower than that of group C (p=0.002), and the rate of antiemetics use in group C was higher than that in group P (p=0.028). The Nausea Vomiting Scale scores of group C were also significantly higher than those of group P (P=0.005). There were no significant differences between the values at 4-12 and 12-24 hours. Conclusion: The administration of a sub hypnotic dose of propofol at the end of surgery was found to be at least as effective as metoclopramide in preventing PONV in the early postoperative period in adult patients undergoing middle ear surgery.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage782en_US
dc.identifier.issn0379-5284
dc.identifier.issue6en_US
dc.identifier.pmid19526159
dc.identifier.startpage778en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4446
dc.identifier.volume30en_US
dc.identifier.wosWOS:000269349300007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleComparison of the efficacy of propofol and metoclopramide in preventing postoperative nausea and vomiting after middle ear surgeryen_US
dc.typeArticle

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