Comparison of the effects of sodium hyaluronate-chondroitin sulphate and corticosteroid in the treatment of lateral epicondylitis: a prospective randomized trial

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dc.contributor.authorTosun, Haci Bayram
dc.contributor.authorGumustas, Seyitali
dc.contributor.authorAgir, Ismail
dc.contributor.authorUludag, Abuzer
dc.contributor.authorSerbest, Sancar
dc.contributor.authorPepele, Demet
dc.contributor.authorErtem, Kadir
dc.date.accessioned2020-06-25T18:12:56Z
dc.date.available2020-06-25T18:12:56Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground Hyaluronic acid and glycosaminoglycans have shown positive effects in improving lateral epicondylitis and other tendinosis conditions. Therefore, we designed a prospective, randomized study to compare the effects of a combined sodium hyaluronate and chondroitin sulfate (HA + CS) injection versus a triamcinolone injection in the treatment of lateral epicondylitis. Methods In total, 57 consecutive patients with clinically diagnosed lateral epicondylitis were divided randomly into two groups. In the HA + CS group, 25 patients received a single injection of a solution containing an HA + CS combination and prilocaine HCl, while the 32 patients in the triamcinolone group received a single injection of a solution of triamcinolone and prilocaine HCl. We evaluated the pain and function outcome measures using the Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire at the beginning of the study, and 3 and 6 months after the injection. Additionally, the Minimum Clinically Important Difference values and percentage changes in the PRTEE subscale scores between the assessments were calculated. Results No serious adverse events were reported throughout the study. The mean pain and function scores for the HA + CS and triamcinolone groups had significantly improved at 3 months, but the mean function scores in the HA + CS group were statistically significantly better when compared to the triamcinolone group. At 6 months, both groups had significantly improved mean pain and function scores, compared to the baseline scores; however, the mean pain and function scores in the 6-month HA + CS treatment group were better than in the 6-month triamcinolone group. The relative change for the mean total score in the HA + CS group was much better when compared with the triamcinolone group, and the HA + CS treatment group showed clinically significant improvement when compared with triamcinolone group at 3 and 6 months. Conclusions This study supports the idea that for a single injection treatment of patients with lateral epicondylitis, a combination injection of HA + CS may offer better pain benefits for 6 months after injection, when compared to triamcinolone. Type of study/level of evidence Level II, Randomized Clinical Trial, Prospective Comparative Study.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00776-015-0747-z
dc.identifier.endpage843en_US
dc.identifier.issn0949-2658
dc.identifier.issn1436-2023
dc.identifier.issue5en_US
dc.identifier.pmid26133944
dc.identifier.scopus2-s2.0-84942293956
dc.identifier.scopusqualityQ2
dc.identifier.startpage837en_US
dc.identifier.urihttps://doi.org/10.1007/s00776-015-0747-z
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6080
dc.identifier.volume20en_US
dc.identifier.wosWOS:000361650300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Orthopaedic Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleComparison of the effects of sodium hyaluronate-chondroitin sulphate and corticosteroid in the treatment of lateral epicondylitis: a prospective randomized trialen_US
dc.typeArticle

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