Do CCR5 (CCR5?32) and TLR3 (RS5743313) gene polymorphisms prevent chronic hepatitis B infection?
[ X ]
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Hepatitis B virus (HBV) is still a significant health problem in human. HBV severity or sensitivity of patients may be based on the individual genetic factors significantly. The aim of this study is to investigate the association of CCR5 (CCR5 Delta 32), TLR3 (rs5743313) functional gene polymorphisms, interferon-gamma (IFN-?) level in HBV infection, which are thought to play an important role in innate and acquired immunity in patients who have undergone HBV seroconversion and those who have chronic hepatitis B disease and receive treatment. One hundred patients who are became naturally immune against HBV infection (HBsAg negative, anti-HBc IgG, and anti-HBs IgG positive), and 100 patients with chronic hepatitis B infection (>6 months HBsAg positive) who are receiving oral antiviral therapy were compared for CCR5 Delta 32, TLR3 (rs5743313) genotypes and serum IFN-gamma level. It was found that CCR5 Delta 32 polymorphism (Wt/Delta 32 and Delta 32/Delta 32) was significantly higher in the chronic hepatitis B group (p=0.048) but not for TLR3 gene polymorphism. However, serum IFN-gamma level was significantly higher in the HBV seroconversion group (75 +/- 89ng/ml) than in the chronic hepatitis B group (4.35 +/- 17.27ng/ml) (p < 0.001). In conclusion, a higher CCR5 Delta 32 allele frequency in patients with chronic hepatitis B might be considered as a marker of progression to chronic hepatitis.
Açıklama
Anahtar Kelimeler
evolution; genetic variability; hepatitis B virus; immune system; pathogenesis; virus classification
Kaynak
Journal of Medical Virology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
95
Sayı
1
