The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts

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dc.authoridOzyildirim, Serhan/0000-0002-9205-5708
dc.contributor.authorAkgun-Unal, Nilufer
dc.contributor.authorOzyildirim, Serhan
dc.contributor.authorUnal, Omer
dc.contributor.authorGulbahce-Mutlu, Elif
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.date.accessioned2025-01-21T16:45:25Z
dc.date.available2025-01-21T16:45:25Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe roles of melatonin and resveratrol-enhanced activation of SIRT1 (silent information regulator 1), GLUT4 (glucose transporter type 4), and PGC-1 alpha (peroxisome proliferator-activated receptor gamma coactivator 1 -alpha) in mediating the protective effects on the heart in aged female rats with streptozotocin-induced dia-betes were investigated. 16-month-old 48 Wistar female rats were separated into 8 groups with equal numbers. Group 1: Control, Group 2: Resveratrol Control, Group 3: Melatonin Control, Group 4: Resveratrol and Melatonin Control, Group 5: Diabetes, Group 6: Diabetes Resveratrol, Group 7: Diabetes Melatonin, Group 8: Diabetes Resveratrol and Melatonin. A single dose of 40 mg/kg intraperitoneal streptozotocin was injected into the rats of Groups 5, 6, 7, and 8 to induce experimental diabetes. Blood glucose levels were measured from the tail veins of the animals six days after the injections, using a diagnostic glucose kit. Rats with a blood glucose levels >= 300 mg/dl were considered diabetic. 5 mg/kg/day of resveratrol (intraperitoneal) and melatonin (subcutaneous) were administered for four weeks. At the end of the applications, SIRT1, GLUT4, PGC-1 alpha gene expression as well as MDA and GSH levels in the heart tissues were determined by the PCR method from heart tissue samples taken under general anesthesia.The findings of our study show that suppressed antioxidant activity and decreased GLUT4, SIRT1, and PGC-1 alpha gene expression in heart tissue can be reversed by the combination of resveratrol, melatonin, and resveratrol + melatonin in a diabetic aged female rat model. Resveratrol and melatonin supplementation may have a pro-tective effect on cardiac functions in the diabetic aged female rat model.
dc.description.sponsorshipSelcuk University Faculty Member Training Program Coordinator [2016-OYP-091]
dc.description.sponsorshipThis study was supported by the Selcuk University Faculty Member Training Program Coordinator (2016-OYP-091).
dc.identifier.doi10.1016/j.exger.2022.112043
dc.identifier.issn0531-5565
dc.identifier.issn1873-6815
dc.identifier.pmid36494013
dc.identifier.scopus2-s2.0-85143966968
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.exger.2022.112043
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25644
dc.identifier.volume172
dc.identifier.wosWOS:000915094600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofExperimental Gerontology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectDiabetes; Melatonin; Resveratrol; Aged female rat; Antioxidant
dc.titleThe effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts
dc.typeArticle

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