Effect of Locally Administered Alendronate on Onlay Grafts

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dc.contributor.authorTekin, Umut
dc.contributor.authorOzgul, Ozkan
dc.contributor.authorTuz, Hakan
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorKocyigit, Ismail Doruk
dc.contributor.authorAtil, Fethi
dc.contributor.authorOnder, M. Ercument
dc.date.accessioned2020-06-25T18:22:52Z
dc.date.available2020-06-25T18:22:52Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionKORKUSUZ, PETEK/0000-0002-7553-3915; Onder, M Ercument/0000-0002-1488-616X
dc.description.abstractObjective: The present study compared the effects of local alendronate application on the osteogenesis of autogenous and xenogenous onlay grafts implanted in rabbit mandibles. Material and Methods: 28 New Zealand rabbits were used in this experimental animal study. The animals were randomly divided into 4 groups according to graft material as follows: D1: autogenous graft-saline; D2: 60% autogenous graft-40% alendronate D3: xenogenous bone graft-saline; D4: 60% xenogenous graft-40% alendronate. 3 histologic parameters were evaluated: the ratio of new bone formation to the total defect area, the active osteoblast-lined bone length, and the ratio of osteocyte-filled lacunae to total lacunae. At the same time, the grafted zones were evaluated using dual-energy X-ray absorptiometry (DEXA) and the Bone mineral density scores were measured. Results: The present study showed better results for the group receiving alendronate applied to autogenous graft when compared to other groups. Discussion: The administration of alendronate increases the resistance of autogenous graft; it may also enhance new bone formation and increase the viability of xenograft. Further animal studies supported with biomechanical tests are required prior to human studies.en_US
dc.description.sponsorshipKirikkale University Scientific Research Project Department [2008-59]en_US
dc.description.sponsorshipThe authors claim to have no financial interest, either directly, or indirectly, in the products or information listed in the article. This study supported by Kirikkale University Scientific Research Project Department. Project No: 2008-59.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1166/jbt.2017.1610
dc.identifier.endpage654en_US
dc.identifier.issn2157-9083
dc.identifier.issn2157-9091
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85027548890
dc.identifier.scopusqualityN/A
dc.identifier.startpage650en_US
dc.identifier.urihttps://doi.org/10.1166/jbt.2017.1610
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6934
dc.identifier.volume7en_US
dc.identifier.wosWOS:000408358800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAmer Scientific Publishersen_US
dc.relation.ispartofJournal Of Biomaterials And Tissue Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlendronateen_US
dc.subjectOnlay Graften_US
dc.subjectRabbit Modelen_US
dc.titleEffect of Locally Administered Alendronate on Onlay Graftsen_US
dc.typeArticle

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