Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat

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dc.contributor.authorBal, Ramazan
dc.contributor.authorUstundag, Yasemin
dc.contributor.authorBulut, Funda
dc.contributor.authorDemir, Caner Feyzi
dc.contributor.authorBal, Ali
dc.date.accessioned2020-06-25T18:16:51Z
dc.date.available2020-06-25T18:16:51Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionBal, Ramazan/0000-0003-3829-8669
dc.description.abstractIntroduction: Tinnitus is defined as a phantom auditory sensation, the perception of sound in the absence of external acoustic stimulation. Given that flufenamic acid (FFA) blocks TRPM2 cation channels, resulting in reduced neuronal excitability, we aimed to investigate whether FFA suppresses the behavioral manifestation of sodium salicylate (SSA)-induced tinnitus in rats. Material and methods: Tinnitus was evaluated using a conditioned lick suppression model of behavioral testing. Thirty-one Wistar rats, randomly divided into four treatment groups, were trained and tested in the behavioral experiment: (1) control group: DMSO + saline (n = 6), (2) SSA group: DMSO + SSA (n = 6), (3) FFA group: FFA (66 mg/kg bw) + saline (n = 9), (4) FFA + SSA group: FFA (66 mg/kg bw) + SSA (400 mg/kg bw) (n = 10). Localization of TRPM2 to the plasma membrane of cochlear nucleus neurons was demonstrated by confocal microscopy. Results: Pavlovian training resulted in strong suppression of licking, having a mean value of 0.05 +/- 0.03 on extinction day 1, which is below the suppression training criterion level of 0.20 in control tinnitus animals. The suppression rate for rats having both FFA (66 mg/kg bw) and SSA (400 mg/kg bw) injections was significantly lower than that for the rats having SSA injections (p < 0.01). Conclusions: We suggest that SSA -induced tinnitus could possibly be prevented by administration of a TRPM2 ion channel antagonist, FFA at 66 mg/kg bw.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-110S397]en_US
dc.description.sponsorshipThe immunohistochemical staining part of the study was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) under Grant No. SBAG-110S397.en_US
dc.identifier.citationBal, R., Ustundag, Y., Bulut, F., Demir, C. F., & Bal, A. (2016). Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat. Archives of medical science : AMS, 12(1), 208–215.en_US
dc.identifier.doi10.5114/aoms.2016.57597
dc.identifier.endpage215en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue1en_US
dc.identifier.pmid26925138
dc.identifier.scopus2-s2.0-85010384409
dc.identifier.scopusqualityQ1
dc.identifier.startpage208en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2016.57597
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6637
dc.identifier.volume12en_US
dc.identifier.wosWOS:000369881500026
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttinnitusen_US
dc.subjectsalicylateen_US
dc.subjectflufenamic aciden_US
dc.subjectTRPM2en_US
dc.subjectexperimentalen_US
dc.subjectraten_US
dc.titleFlufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the raten_US
dc.typeArticle

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