Antileukotrienes in Upper Airway Inflammatory Diseases

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dc.contributor.authorCingi, Cemal
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorIpci, Kağan
dc.contributor.authorŞahin, Ethem
dc.date.accessioned2020-06-25T18:12:43Z
dc.date.available2020-06-25T18:12:43Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractLeukotrienes (LTs) are a family of inflammatory mediators including LTA(4), LTB4, LTC4, LTD4, and LTE4. By competitive binding to the cysteinyl LT1 (CysLT(1)) receptor, LT receptor antagonist drugs, such as montelukast, zafirlukast, and pranlukast, block the effects of CysLTs, improving the symptoms of some chronic respiratory diseases, particularly bronchial asthma and allergic rhinitis. We reviewed the efficacy of antileukotrienes in upper airway inflammatory diseases. An update on the use of antileukotrienes in upper airway diseases in children and adults is presented with a detailed literature survey. Data on LTs, antileukotrienes, and antileukotrienes in chronic rhinosinusitis and nasal polyps, asthma, and allergic rhinitis are presented. Antileukotriene drugs are classified into two groups: CysLT receptor antagonists (zafirlukast, pranlukast, and montelukast) and LT synthesis inhibitors (5-lipoxygenase inhibitors such as zileuton, ZD2138, Bay X 1005, and MK-0591). CysLTs have important proinflammatory and profibrotic effects that contribute to the extensive hyperplastic rhinosinusitis and nasal polyposis (NP) that characterise these disorders. Patients who receive zafirlukast or zileuton tend to show objective improvements in, or at least stabilisation of, NP. Montelukast treatment may lead to clinical subjective improvement in NP. Montelukast treatment after sinus surgery can lead to a significant reduction in eosinophilic cationic protein levels in serum, with a beneficial effect on nasal and pulmonary symptoms and less impact in NP. Combined inhaled corticosteroids and long-acting beta-agonists treatments are most effective for preventing exacerbations among paediatric asthma patients. Treatments with medium-or high-dose inhaled corticosteroids, combined inhaled corticosteroids and LT receptor antagonists, and low-dose inhaled corticosteroids have been reported to be equally effective. Antileukotrienes have also been reported to be effective for allergic rhinitis.en_US
dc.description.sponsorshipContinuous Education and Scientific Research Associationen_US
dc.description.sponsorshipWith exception of data collection, preparation of this paper including design and planning was supported by Continuous Education and Scientific Research Association.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s11882-015-0564-7
dc.identifier.issn1529-7322
dc.identifier.issn1534-6315
dc.identifier.issue11en_US
dc.identifier.pmid26385352
dc.identifier.scopus2-s2.0-84942414834
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s11882-015-0564-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6021
dc.identifier.volume15en_US
dc.identifier.wosWOS:000363025500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCurrent Medicine Groupen_US
dc.relation.ispartofCurrent Allergy And Asthma Reports
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeukotrienesen_US
dc.subjectAntileukotriene drugsen_US
dc.subjectAsthmaen_US
dc.subjectChronic rhinosinusitis with nasal polyposisen_US
dc.subjectAllergic rhinitisen_US
dc.titleAntileukotrienes in Upper Airway Inflammatory Diseasesen_US
dc.typeReview Article

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