Effects of weight loss on metabolic control, blood pressure, carotid intima-media thickness and abdominal fat distribution in obese geriatric women

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dc.contributor.authorVarlı, Murat
dc.contributor.authorYağmurlu, Banu
dc.contributor.authorAras, Sevgi
dc.contributor.authorAtlı, Teslime
dc.contributor.authorErdoğan, Gürbüz
dc.date.accessioned2020-06-25T17:51:13Z
dc.date.available2020-06-25T17:51:13Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionVarli, Murat/0000-0003-1176-5255; ARAS, Sevgi/0000-0002-5356-303X
dc.description.abstractBackground and aims: Obesity is a growing health concern worldwide. Few studies have examined the effects of weight loss on metabolic and cardiovascular risk factors in obese elderly. We, therefore, examined the effects of weight loss on metabolic and cardiovascular risk factors such as blood pressure, carotid intima-media thickness, and abdominal fat distribution in obese geriatric women. Methods: Thirteen obese women aged 66-83 years (mean age 71.2 +/- 4.9 yrs) with a body mass index of 35.6-49 kg/m(2) (mean body mass index 39.9 +/- 4.3 kg/m(2)) were evaluated. Only subjects with uncomplicated obesity were included. Anthropometric parameters, lipid levels, glycemic control, insulin sensitivity homocysteine levels, blood pressure, carotid intima-media thickness and abdominal fat distribution were made before and after a 6-month Orlistat plus hypocaloric diet. Results: Subjects lost an average of 8.4 +/- 1.2 kg (9.4%). Total cholesterol, hemoglobin A1c, fasting insulin, and insulin resistance decreased significantly, whereas other parameters including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglyceride, and homocystein did not change after weight loss. In addition, substantial reductions of 24-hour ambulatory systolic and nighttime systolic blood pressures were observed at the end of the study, but not the diastolic blood pressure associated with weight loss. Both carotid intima-media thickness and abdominal fat thicknesses such as intra-abdominal fat and subcutaneous fat decreased significantly after weight loss. Conclusions: Moderate weight loss over 6 months in uncomplicated obese older women produced substantial improvements in the cholesterol levels, hemoglobin A1c, insulin resistance and other cardiovascular risk factors including blood pressure, carotid intima-media thickness and abdominal fat distribution. Obesity and Metabolism 2010; 6: 50-56.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage56en_US
dc.identifier.issn1825-3865
dc.identifier.issn1826-7572
dc.identifier.issue2-3en_US
dc.identifier.scopus2-s2.0-78651332350
dc.identifier.scopusqualityQ3
dc.identifier.startpage50en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4737
dc.identifier.volume6en_US
dc.identifier.wosWOS:000285727900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofObesity And Metabolism-Milan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular risk factorsen_US
dc.subjectelderlyen_US
dc.subjectinsulin resistanceen_US
dc.subjectobesityen_US
dc.subjectweight lossen_US
dc.titleEffects of weight loss on metabolic control, blood pressure, carotid intima-media thickness and abdominal fat distribution in obese geriatric womenen_US
dc.typeArticle

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