Effects of fullerene C60 on liver tissue in liver ischemia reperfusion injury in rats undergoing sevoflurane anesthesia

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridYavuz, Aydin/0000-0003-0091-7997
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.authoridTas Tuna, Ayca/0000-0001-6764-2647
dc.authoridOzdemir, Cagri/0000-0002-1266-8054
dc.contributor.authorYavuz, Aydin
dc.contributor.authorTuna, Ayca Tas
dc.contributor.authorOzdemir, Cagri
dc.contributor.authorMortas, Tulay
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorKasapbasi, Esat
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2025-01-21T16:38:17Z
dc.date.available2025-01-21T16:38:17Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study aimed to investigate the effects of fullerene C60 on rat liver tissue in a liver ischemia reperfusion injury (IRI) model under sevoflurane anesthesia to evaluate the ability of nanoparticles to prevent hepatic complications. A total of 36 adult female Wistar Albino rats were divided into six groups, each containing six groups as follows: sham group (Group S), fullerene C60 group (Group FC60), ischemia-reperfusion group (Group IR), ischemia-reperfusion-sevoflurane group (Group IR-Sevo), ischemia-reperfusion-fullerene C60 group (Group IR-FC60), and ischemia-reperfusion-fullerene C60-sevoflurane group (Group IR-FC60-Sevo). Fullerene C60 100 mg/kg was administered to IR-FC60 and IR-FC60-Sevo groups. In the IR group, 2 h of ischemia and 2 h of reperfusion were performed. At the end of reperfusion, liver tissues were removed for biochemical assays and histopathological examinations. Hepatocyte degeneration, sinusoidal dilatation, prenecrotic cells, and mononuclear cell infiltration in the parenchyma were significantly higher in Group IR than in all other groups. Thiobarbituric acid reactive substances levels were significantly higher in Group IR than in the other groups, and the lowest thiobarbituric acid reactive substances level was in Group IR-FC60 than in the other groups, except for Groups S and FC60. Catalase and Glutathione-S-transferase activities were reduced in the IR group compared to all other groups. Fullerene C60 had protective effects against liver IR injury in rats under sevoflurane anesthesia. The use of fullerene C60 could reduce the adverse effects of IRI and the associated costs of liver transplantation surgery.
dc.identifier.doi10.1080/19932820.2023.2281116
dc.identifier.issn1993-2820
dc.identifier.issn1819-6357
dc.identifier.issue1
dc.identifier.pmid37976165
dc.identifier.scopus2-s2.0-85177176519
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/19932820.2023.2281116
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24625
dc.identifier.volume18
dc.identifier.wosWOS:001103826200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofLibyan Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectFullerene C60; nanoparticle; ischemia reperfusion; sevoflurane; liver
dc.titleEffects of fullerene C60 on liver tissue in liver ischemia reperfusion injury in rats undergoing sevoflurane anesthesia
dc.typeArticle

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