Ankyloglossia in Dogs: A Morphological and Immunohistochemical Study

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dc.contributor.authorKarahan, Siyami
dc.contributor.authorKul, Bengi Çınar
dc.date.accessioned2020-06-25T17:48:29Z
dc.date.available2020-06-25T17:48:29Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptioncinar kul, bengi/0000-0002-8955-0097;
dc.description.abstractAnkyloglossia is a congenital anomaly of the tongue that is usually characterized by a short and thick lingual frenulum. The genetic mutations such as in TBox genes and other foetal mechanism have still been under investigation as possible causes of ankyloglossia. This study describes morphology of anklyoglossia phenotype found in members of two closely bred Kangal dog families. Morphology of ankyloglossia and immunohistochemical localization of alpha B-crystallin, an anti-apoptotic protein, in the frenulum tissue collected during frenectomy was described. Grossly, the lingual frenulum was observed as it extended up to the tip or near the tip of the tongue. The tip of the tongue was often notched and appeared in 'W' shape. No other craniofacial anomalies were associated with ankyloglossia. Histologically, the frenulum tissue was covered by stratified squamous epithelia of variable thickness. Skeletal muscle fibres were often scattered in the vicinity of collagen fibres of the lamina propria. alpha B-crystallin was immunolocalized exclusively in skeletal muscle fibres. In conclusion, ankyloglossia in the dog generally occurs as a sole anomaly. The presence of alpha B-crystallin immunoreactivity exclusively in skeletal muscle fibres suggests that there may be a connection between occurrences of ankyloglossia in the dog and a delay or interference with apoptosis of the skeletal fibres in the frenulum tissue.en_US
dc.description.sponsorshipKirikkale UniversityKirikkale University [2007/27]en_US
dc.description.sponsorshipThis is study is supported by a grant by the Kirikkale University (project number: 2007/27).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1439-0264.2008.00907.x
dc.identifier.endpage121en_US
dc.identifier.issn0340-2096
dc.identifier.issue2en_US
dc.identifier.pmid19007356
dc.identifier.scopus2-s2.0-62249216426
dc.identifier.scopusqualityQ2
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0264.2008.00907.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4465
dc.identifier.volume38en_US
dc.identifier.wosWOS:000264021500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell Publishing, Incen_US
dc.relation.ispartofAnatomia Histologia Embryologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAnkyloglossia in Dogs: A Morphological and Immunohistochemical Studyen_US
dc.typeArticle

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