The Effects of Resveratrol and Melatonin on Cardiac Dysfunction in Diabetic Elderly Female Rats

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dc.authoridOzyildirim, Serhan/0000-0002-9205-5708
dc.contributor.authorAkgun-Unal, Nilufer
dc.contributor.authorOzyildirim, Serhan
dc.contributor.authorUnal, Omer
dc.contributor.authorBaltaci, Saltuk Bugra
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.date.accessioned2025-01-21T16:45:26Z
dc.date.available2025-01-21T16:45:26Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe aimed to investigate the effects of melatonin and resveratrol on diabetes-related papillary muscle dysfunction and structural heart disorders. The protective effect of resveratrol and melatonin supplementation on cardiac functions was investigated in a diabetic elderly female rat model. 16-month-old rats (n=48) were allocated into 8 groups. Group1: Control, Group2: Resveratrol Control, Group3: Melatonin Control, Group4: Resveratrol and Melatonin Control, Group5: Diabetes, Group6: Diabetes Resveratrol, Group7: Diabetes Melatonin, Group8: Diabetes Resveratrol and Melatonin. Streptozotocin was injected intraperitoneally to the rats for experimental diabetes induction. Thereafter, resveratrol (intraperitoneal) and melatonin (subcutaneous) were administered for 4 weeks. Resveratrol and melatonin had a protective effect on the contractile parameters and structural properties of the papillary muscle, which was impaired by diabetes. it has been presented that diabetes impairs the contractile function of the papillary muscle for each stimulus frequency tested and the responses obtained as a result of Ca+2 uptake and release mechanisms from the Sarcoplasmic reticulum, and it has been observed that these effects are improved with resveratrol and melatonin injection. The decrease in myocardial papillary muscle strength in the diabetic elderly female rat can be reversed with the combination of resveratrol, melatonin and resveratrol+melatonin. Melatonin+resveratrol supplementation is no different from melatonin and/or resveratrol supplementation. Resveratrol and melatonin supplementation may have a protective effect on cardiac functions in a diabetic elderly female rat model.
dc.description.sponsorshipSelcuk University [2016-OYP-091]
dc.description.sponsorshipThis study was supported by the Selcuk University Faculty Member Training Program Coordinator (2016-OYP-091).
dc.identifier.doi10.33549/physiolres.935024
dc.identifier.endpage198
dc.identifier.issn0862-8408
dc.identifier.issn1802-9973
dc.identifier.issue2
dc.identifier.pmid37159853
dc.identifier.scopus2-s2.0-85158161545
dc.identifier.scopusqualityQ3
dc.identifier.startpage187
dc.identifier.urihttps://doi.org/10.33549/physiolres.935024
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25645
dc.identifier.volume72
dc.identifier.wosWOS:001057117900006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcad Sciences Czech Republic, Inst Physiology
dc.relation.ispartofPhysiological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectDiabetes; Cardiac dysfunction; Melatonin; Resveratrol; Rapillary papillary muscle
dc.titleThe Effects of Resveratrol and Melatonin on Cardiac Dysfunction in Diabetic Elderly Female Rats
dc.typeArticle

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