Effects of Caproic and Caprylic Acids on Microbial Growth and Cytotoxicity

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dc.contributor.authorHismiogullari, S. E.
dc.contributor.authorElyurek, E.
dc.contributor.authorHismiogullari, A. A.
dc.contributor.authorSahin, F.
dc.contributor.authorBasalan, M.
dc.contributor.authorYenice, S.
dc.date.accessioned2020-06-25T17:44:35Z
dc.date.available2020-06-25T17:44:35Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn order to assess the potential use of fatty acids and their derivatives as alternatives to the regionally banned antibiotics, the bacteriocidal and cytotoxic effects of caproic (hexanoic) and caprylic (octanoic) acids were investigated. Fatty acids at various concentrations were added to media containing Staphylococcus aureus, Escherichia coli and murine fibroblast cells. At 0.5% (w/v) concentration of hexanoic acid, both S. aureus and E. coli growth occurred, however, octanoic acid was effective on inhibition of growth of both bacteria above 1% level. At the same time octanoic acid above 0.5%, hexanoic acid above 0.25% levels inhibited mammalian cell growth. Both acids decreased the medium pH linearly with increasing concentration. Further investigation is needed to prove that they may be usable for in vivo applications.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage735en_US
dc.identifier.issn1680-5593
dc.identifier.issn1993-601X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-53949120468
dc.identifier.scopusqualityN/A
dc.identifier.startpage731en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4147
dc.identifier.volume7en_US
dc.identifier.wosWOS:000262561000019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMedwell Onlineen_US
dc.relation.ispartofJournal Of Animal And Veterinary Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHexanoic aciden_US
dc.subjectoctanoic aciden_US
dc.subjectS. aureusen_US
dc.subjectE. colien_US
dc.subjectcytotoxicityen_US
dc.titleEffects of Caproic and Caprylic Acids on Microbial Growth and Cytotoxicityen_US
dc.typeArticle

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