Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia-reperfusion injury in rats

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dc.contributor.authorErer, Dilek
dc.contributor.authorOzer, Abdullah
dc.contributor.authorDemirtas, Huseyin
dc.contributor.authorGonul, Ipek Isik
dc.contributor.authorKara, Halil
dc.contributor.authorArpaci, Hande
dc.contributor.authorKucuk, Aysegul
dc.date.accessioned2020-06-25T18:17:13Z
dc.date.available2020-06-25T18:17:13Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractObjectives: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental rat model. Materials and methods: Wistar albino rats underwent 2 hours of ischemia via infrarenal aorta clamping with subsequent 2 hours of reperfusion. Alprostadil and iloprost were given starting simultaneously with the reperfusion period. Effects of agents on renal, lung, and skeletal muscle (gastrocnemius) tissue specimens were examined. Results: Renal medullary congestion, cytoplasmic swelling, and mean tubular dilatation scores were significantly lower in the alprostadil-treated group than those found in the I/R-only group (P<0.0001, P=0.015, and P<0.01, respectively). Polymorphonuclear leukocyte infiltration, pulmonary partial destruction, consolidation, alveolar edema, and hemorrhage scores were significantly lower in alprostadil- and iloprost-treated groups (P=0.017 and P=0.001; P<0.01 and P<0.0001). Polymorphonuclear leukocyte infiltration scores in skeletal muscle tissue were significantly lower in the iloprost-treated group than the scores found in the nontreated I/R group (P<0.0001). Conclusion: Alprostadil and iloprost significantly reduce lung tissue I/R injury. Alprostadil has more prominent protective effects against renal I/R injury, while iloprost is superior in terms of protecting the skeletal muscle tissue against I/R injury.en_US
dc.identifier.citationErer, D., Özer, A., Demirtaş, H., Gönül, İ. I., Kara, H., Arpacı, H., Çomu, F. M., Oktar, G. L., Arslan, M., & Küçük, A. (2016). Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia-reperfusion injury in rats. Drug design, development and therapy, 10, 2651–2658.en_US
dc.identifier.doi10.2147/DDDT.S110529
dc.identifier.endpage2658en_US
dc.identifier.issn1177-8881
dc.identifier.pmid27601882
dc.identifier.scopus2-s2.0-84985906122
dc.identifier.scopusqualityQ1
dc.identifier.startpage2651en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S110529
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6719
dc.identifier.volume10en_US
dc.identifier.wosWOS:000382210800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development And Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalprostadilen_US
dc.subjectiloprosten_US
dc.subjectischemia reperfusion injuryen_US
dc.subjectraten_US
dc.subjectrenalen_US
dc.subjectlungen_US
dc.subjectskeletal muscleen_US
dc.titleEffects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia-reperfusion injury in ratsen_US
dc.typeArticle

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