Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats

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dc.authoridUNLUKAL, NEJAT/0000-0002-8107-4882
dc.contributor.authorGumus, Meltem
dc.contributor.authorGulbahce-Mutlu, Elif
dc.contributor.authorUnal, Omer
dc.contributor.authorBaltaci, Saltuk Bugra
dc.contributor.authorUnlukal, Nejat
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.date.accessioned2025-01-21T16:42:28Z
dc.date.available2025-01-21T16:42:28Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study was to investigate how zinc deficiency and supplementation affect liver markers including autotaxin, kallistatin, endocan, and zinc carrier proteins ZIP14 and ZnT9 in rats exposed to maternal zinc deficiency. Additionally, the study aimed to assess liver tissue damage through histological examination. A total of forty male pups were included in the research, with thirty originating from mothers who were given a zinc-deficient diet (Groups 1, 2, and 3), and the remaining ten born to mothers fed a standard diet (Group 4). Subsequently, Group 1 was subjected to a zinc-deficient diet, Group 2 received a standard diet, Group 3 received zinc supplementation, and Group 4 served as the control group without any supplementation. Upon completion of the experimental phases of the study, all animals were sacrificed under general anesthesia, and samples of liver tissue were obtained. The levels of autotaxin, kallistatin, endocan, ZIP 14, and ZnT9 in these liver tissue samples were determined using the ELISA technique. In addition, histological examination was performed to evaluate tissue damage in the liver samples. In the group experiencing zinc deficiency, both endocan and autotaxin levels increased compared to the control group. With zinc supplementation, the levels of endocan and autotaxin returned to the values observed in the control group. Similarly, the suppressed levels of kallistatin, ZIP14, and ZnT9 observed in the zinc deficiency group were reversed with zinc supplementation. Likewise, the reduced levels of kallistatin, ZIP14, and ZnT9 seen in the zinc deficiency group were rectified with zinc supplementation. Moreover, the application of zinc partially ameliorated the heightened liver tissue damage triggered by zinc deficiency. This study is the pioneering one to demonstrate that liver tissue dysfunction induced by a marginal zinc-deficient diet in rats with marginal maternal zinc deficiency can be alleviated through zinc supplementation.
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University (SUBAPK) [20401093]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 20401093)
dc.identifier.doi10.1007/s12011-023-03824-8
dc.identifier.endpage2142
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue5
dc.identifier.pmid37656390
dc.identifier.scopus2-s2.0-85169342032
dc.identifier.scopusqualityQ1
dc.identifier.startpage2133
dc.identifier.urihttps://doi.org/10.1007/s12011-023-03824-8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25084
dc.identifier.volume202
dc.identifier.wosWOS:001056971900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectMaternal zinc deficiency; Zinc; Liver markers; ZIP14; ZnT9
dc.titleMarginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats
dc.typeArticle

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