5-fluorouracil as chemoadjuvant for primary pterygium surgery: Preliminary report

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dc.contributor.authorAkarsu, C
dc.contributor.authorTaner, P
dc.contributor.authorErgin, A
dc.date.accessioned2020-06-25T17:35:23Z
dc.date.available2020-06-25T17:35:23Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose. To investigate the safety and efficacy of intraoperative application of 5-fluorouracil as an adjuvant in primary pterygium surgery and to evaluate the effect of postoperative subconjunctival 5-fluorouracil injections on the recurrent pterygium. Methods. Of 25 consecutive white patients, 28 eyes with primary pterygium underwent pterygium excision with intraoperative application of 5-fluorouracil (25 mg/mL for 3 minutes). The superior and inferior conjunctiva was approximated to cover the scleral bed within I mm of the limbus. Recurrence of pterygium was defined as postoperative fibrovascular growth more than 1 mm onto the cornea. Eyes with recurrence less than 2 mm were treated with subconjunctival 5-fluorouracil injections. Results. After a mean follow-up of 14.1 +/- 3.9 months (mean +/- standard deviation), 7 recurrences (25%) were observed. All recurrences were detected within 12 months. In 4 of 7 recurrences, the fibrovascular growths were less than 2 mm. We, therefore, performed subconjunctival 5-fluorouracil injections. In 3 (75%) of 4 recurrences, the fibrovascular growths became atrophic. No serious complications were observed during and after the surgery. However, superficial punctate keratitis,:Pain, and hyperemia were detected in all patients in the early postoperative period. As a result, of 28 eyes, 4 (14%) had unacceptable cosmetic results and growing recurrences. Conclusions. This study suggests that intraoperative applications of 5-fluorouracil is both efficient and safe in the treatment of primary pterygium. Additionally, postoperative subconjunctival 5-fluorouracil injections may prevent the progression of fibrovascular tissue.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/00003226-200308000-00007
dc.identifier.endpage526en_US
dc.identifier.issn0277-3740
dc.identifier.issue6en_US
dc.identifier.pmid12883344
dc.identifier.scopus2-s2.0-0041342968
dc.identifier.scopusqualityQ1
dc.identifier.startpage522en_US
dc.identifier.urihttps://doi.org/10.1097/00003226-200308000-00007
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3107
dc.identifier.volume22en_US
dc.identifier.wosWOS:000184750700007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCornea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpterygiumen_US
dc.subject5-fluorouracilen_US
dc.subjectrecurrenceen_US
dc.subjectfinal appearanceen_US
dc.title5-fluorouracil as chemoadjuvant for primary pterygium surgery: Preliminary reporten_US
dc.typeArticle

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