Antioxidant potential of Ginkgo biloba leaf extract against uranium-induced genotoxicity and oxidative stress in albino mice

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dc.contributor.authorÇavuşoğlu, Kültigin
dc.contributor.authorYapar, Kürşad
dc.contributor.authorYalçın, Emine
dc.date.accessioned2020-06-25T17:48:48Z
dc.date.available2020-06-25T17:48:48Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractUranium is a highly radioactive heavy metal with isotopes that decay on the geological time scale. Uranium is known to induce chromosomal damages and oxidative stress. In the present study, we investigated the protective role of Ginkgo biloba (GB) leaf extract on uranyl acetate (U-235)-induced toxicity in Swiss albino mice. For this purpose, we performed the chromosome aberration (CA) test and mouse-erythrocyte micronucleus (Mus-EMN) assay in the erythrocyte, bone marrow and exfoliated buccal mucosa cells. Blood malondialdehyde (MDA) and glutathione (GSH) levels were also determined. The animals were randomly divided into six groups, each consisting of six animals. They were treated with 5 mg/kg b.wt uranium by oral gavage for 5 days. GB extract (50 and 150 mg/kg b.wt) was administered by oral gavage at 48 h, 24 h, and 15 min before uranium application. As a result, uranium-only treated mice presented higher frequency of CAs, micronuclei (MN) and abnormal metaphases (AM) when compared to the controls. These mice also displayed lower mean mitotic index (MI) than the controls. Moreover, there was a significant increase (P<0.05) in MDA levels, but a significant decrease (P<0.05) in GSH levels, when compared to the controls. Pretreatment of mice with GB significantly decreased the MN frequency in the erythrocyte cells. Similarly, the number of abnormal metaphases (AM) and the frequency of CAs, such as break, acentric, fragment, gap and ring, were fairly decreased and the value of MI was increased. In addition, the frequency of MN in the erythrocytes was greater than those in the exfoliated cells of buccal mucosa. Moreover, GB supplementation caused a dose-dependent amelioration in the oxidative stress. These findings suggested that GB leaf extract has a protective effect against uranium-induced genotoxicity and oxidative stress in albino mice, due to its antioxidant properties.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage1558en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-70349897916
dc.identifier.scopusqualityN/A
dc.identifier.startpage1551en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4564
dc.identifier.volume18en_US
dc.identifier.wosWOS:000270702200002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChromosomal aberrationsen_US
dc.subjectexfoliated cellsen_US
dc.subjectGingko bilobaen_US
dc.subjectmicronucleien_US
dc.subjecturaniumen_US
dc.titleAntioxidant potential of Ginkgo biloba leaf extract against uranium-induced genotoxicity and oxidative stress in albino miceen_US
dc.typeArticle

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