The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats

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dc.contributor.authorTuncay, Aydin
dc.contributor.authorSivgin, Volkan
dc.contributor.authorOzdemirkan, Aycan
dc.contributor.authorSezen, Saban Cenn
dc.contributor.authorBoyunaga, Hakan
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorGunes, Sin
dc.date.accessioned2021-01-14T18:10:58Z
dc.date.available2021-01-14T18:10:58Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionOzdemirkan, Aycan/0000-0001-5324-0348; gunes, isin/0000-0001-6438-8153
dc.description.abstractIntroduction: We aimed to investigate the effects of cerium oxide, applied before the sevoflurane anesthesia, on lung tissue in rats with lower extremity ischemia-reperfusion (IR). Materials and Methods: A total of 30 rats were randomly divided into five groups as; control (C), IR, cerium oxide-IR (CO-IR), IR-sevoflurane (IRS), and cerium oxide-IR-sevoflurane (CO-IRS). In the CO-IR group, 30 minutes after the injection of cerium oxide (0.5 mg/kg, intraperitoneal (i.p)), an atraumatic microvascular clamp was placed on the infrarenal abdominal aorta for 120 minutes. Then, the clamp was removed and reperfused for 120 minutes. Sevoflurane was applied in 100% oxygen at a rate of 2.3% at 4 L/min during IR. The blood samples were taken for biochemical analysis and the lung tissue samples were taken for histological analysis. Results: Neutrophil infiltration/aggregation was significantly higher in the IR group than in the C and CO-IRS groups. The alveolar wall thickness and total lung injury scores were significantly higher in the IR group than in the C, IRS, CO-IR and CO-IRS groups. Discussion: We determined that the administration of 0.5 mg/kg dose of cerium oxide with sevoflurane reduces the oxidative stress and corrects IR-related damage in lung tissue. Our results show that the administration of cerium oxide before IR and the administration of sevoflurane during IR have a protective effect in rats.en_US
dc.identifier.citationTuncay A, Sivgin V, Ozdemirkan A, Sezen SC, Boyunaga H, Kucuk A, Gunes I, Arslan M. (2020). The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats. Int J Nanomedicine.15, 7481-7489.en_US
dc.identifier.doi10.2147/IJN.S263001
dc.identifier.endpage7489en_US
dc.identifier.issn1178-2013
dc.identifier.pmid33116483
dc.identifier.scopus2-s2.0-85094935887
dc.identifier.scopusqualityQ1
dc.identifier.startpage7481en_US
dc.identifier.urihttps://doi.org/10.2147/IJN.S263001
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12837
dc.identifier.volume15en_US
dc.identifier.wosWOS:000576677600002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDOVE MEDICAL PRESS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF NANOMEDICINE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcerium oxideen_US
dc.subjectsevofluraneen_US
dc.subjectischemia reperfusionen_US
dc.subjectbiochemical analysisen_US
dc.subjecthistopathological analysisen_US
dc.titleThe Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Ratsen_US
dc.typeArticle

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