Changes in neuropeptide y tissue concentration in the wall of the rat urinary bladder after acute distension

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dc.contributor.authorYılmaz, Erdal
dc.contributor.authorArıkan, Nihat
dc.date.accessioned2020-06-25T17:40:47Z
dc.date.available2020-06-25T17:40:47Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractNeuropeptide Y (NPY) is known to be associated with the adrenergic system. The relationship among the late micturition disorders following acute urinary distension, the adrenergic system and NPY was investigated. A total of 90 rats were included in the study of which 30 acted as the control group. Acute urinary distension was created in 60 rats. The NPY concentration within their bladders was assessed by the use of radioimmunoassay (RIA) at 3 h after distension and subsequently on days 2, 7 and 21, then the third and sixth months. The NPY concentrations assessed in the third and sixth months were compared with the control group in the same age group. By means of the RIA method, a substantial decline of NPY concentration was observed at 2 days after distension, while the concentration started to increase after day 7 (P=0.003). This increase continued until the twenty first day (P=0.004). However, a significant decline was maintained when compared to the concentration before distension. In the third and sixth months, a significant decline were observed in the NPY concentration in comparison to the control group (P=0.004 and P=0.005, respectively). Early and late micturition disorders experienced after acute urinary distension may be the result of adrenergic denervation which may be related to NPY.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00240-004-0447-1
dc.identifier.endpage60en_US
dc.identifier.issn0300-5623
dc.identifier.issn1434-0879
dc.identifier.issue1en_US
dc.identifier.pmid15619124
dc.identifier.scopus2-s2.0-16844373757
dc.identifier.scopusqualityN/A
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-004-0447-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3550
dc.identifier.volume33en_US
dc.identifier.wosWOS:000227736400008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofUrological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecturinary bladderen_US
dc.subjectraten_US
dc.subjectacuteen_US
dc.subjectdistensionen_US
dc.subjectneuropeptide Yen_US
dc.subjectmicturitionen_US
dc.subjectdisordersen_US
dc.titleChanges in neuropeptide y tissue concentration in the wall of the rat urinary bladder after acute distensionen_US
dc.typeArticle

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