Antioxidative and Immunomodulatory Effects of A-Lipoic Acid in Rat Colitis Model Induced by Acetic Acid

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dc.contributor.authorErgul, Bilal
dc.contributor.authorDogan, Zeynal
dc.contributor.authorSarikaya, Murat
dc.contributor.authorFilik, Levent
dc.contributor.authorUtku, Ozlem Gul
dc.contributor.authorGonultas, Mehmet
dc.contributor.authorCan, Murat
dc.date.accessioned2020-06-25T18:34:36Z
dc.date.available2020-06-25T18:34:36Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Benefit of alpha-Lipoic acid (ALA) was previously shown in rat-colitis model via suppression of neutrophil accumulation, preservation of endogenous glutathione and inhibition of reactive oxidant generation. Ulcerative colitis is a chronic inflammatory condition of the colon and cytokines (such as TNF-alpha, IL-1 beta and TGF-beta) are crucial components of these inflammatory pathways. Hence, the present study was undertaken to evaluate the antioxidative and immunomodulatory effects of ALA on experimental colitis model induced by acetic acid in Wistar albino rats. Methods: Mice received either a control diet or ALA-supplemented diet for 14 d. Colitis was induced by acetic acid administration at 7th day. Mucosal damage and the activation of immune cells and cytokines were determined by macroscopic score, histological score, tissue cytokine levels (TNF-alpha, IL-1 beta and TGF-beta). Anti-oxidant effect of ALA was determined by Malondialdehyde, and total antioxidative status. Results: Disease activity Index was significantly higher in colitis group compared to control, ALA and ALA-colitis groups (p<0.001). No significant difference was found between DAI of control, ALA and ALA-colitis groups. The inflammatory mediators, TNF-alpha and IL-1 beta, and MDA were elevated in colitis group compared to other groups (p<0.001, p<0.001 respectively). TGF-beta and total antioxidative status were significantly lower in colitis group (p<0.001). Conclusion: ALA may possibly have some therapeutic usefulness in the management of ulcerative colitis.en_US
dc.identifier.doi10.12996/gmj.2019.33
dc.identifier.endpage129en_US
dc.identifier.issn2147-2092
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85064408951
dc.identifier.scopusqualityQ4
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.12996/gmj.2019.33
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7970
dc.identifier.volume30en_US
dc.identifier.wosWOS:000462182300003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGazi Univ, Fac Meden_US
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalpha-Lipoic aciden_US
dc.subjectulcerative colitisen_US
dc.subjectTNF-alphaen_US
dc.subjectIL-1 betaen_US
dc.subjectTGF-betaen_US
dc.subjectMDAen_US
dc.subjectTASen_US
dc.subjectantioxidative effecten_US
dc.titleAntioxidative and Immunomodulatory Effects of A-Lipoic Acid in Rat Colitis Model Induced by Acetic Aciden_US
dc.typeArticle

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