Isolation and identification of Clostridium difficile from cases of diarrhea in young farm animals, and the determination of antimicrobial susceptibility

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dc.contributor.authorÖzgen, Ediz Kağan
dc.contributor.authorYıldırım, Murat
dc.date.accessioned2025-01-21T16:34:29Z
dc.date.available2025-01-21T16:34:29Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractClostridium difficile was isolated for the first time in 1935 from fecal samples of infants, although it was not until 1978 that its pathogenicity started to be considered, when it was shown to cause antibiotic-associated diarrhea and pseudomembranous colitis. In this study, it was aimed to determine the virulence and antibiotic resistance profiles of C. dificile in young ruminants with diarrhea and chickens fed on the farm. A total of 200 fecal samples (50 from calves, 50 from lambs and 50 from kid goats with neonatal diarrhea, as well as 50 cloacal swab samples taken from chickens) were taken and analyzed. C. difficile was isolated from 58 of the fecal samples (29.0%), being isolated from 35 of the fecal samples taken from calves (70.0%), 15 from lambs (30.0%), seven from kid goats (14.0%) and one from chickens (2.0%), and of these, 28 isolates were found to have toxigenic characteristics (48.2%) following species identification and toxin characterization. In the following stage, antimicrobial susceptibility tests were performed for a total of 24 toxigenic strains using the microbroth dilution method, and the toxigenic isolates were found to be resistant to ampicillin, cefoxitin, clindamycin, penicillin and tetracycline. The study identified the presence of toxigenic C. difficile in diarrhea cases in neonatal calves and lambs for the first time in our country.
dc.identifier.doi10.3906/vet-2008-94
dc.identifier.endpage271
dc.identifier.issn1300-0128
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85106345201
dc.identifier.scopusqualityQ3
dc.identifier.startpage266
dc.identifier.trdizinid485976
dc.identifier.urihttps://doi.org/10.3906/vet-2008-94
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay485976
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23975
dc.identifier.volume45
dc.identifier.wosWOS:000642323400009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Veterinary & Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectClostridium difficile; antimicrobial susceptibility test; Erzurum; neonatal; Farm animal; calf
dc.titleIsolation and identification of Clostridium difficile from cases of diarrhea in young farm animals, and the determination of antimicrobial susceptibility
dc.typeArticle

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