Comparison of polymethoxyethylacrylate-coated circuits with leukocyte filtration and reduced heparinization protocol on heparin-bonded circuits in different risk cohorts

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dc.contributor.authorGünaydin, Serdar
dc.contributor.authorMcCusker, Kevin
dc.contributor.authorVijay, Venkataramana
dc.contributor.authorİşbir, Selim
dc.contributor.authorSari, Tamer
dc.contributor.authorOnur, Mehmet Ali
dc.contributor.authorZorlutuna, Yaman
dc.date.accessioned2020-06-25T17:41:15Z
dc.date.available2020-06-25T17:41:15Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.descriptionAnnual Seminar of the American-Academy-of-Cardiovascular Perfusion -- JAN 27-30, 2006 -- Reno, NV
dc.descriptionONUR, MEHMET/0000-0002-3630-7982; Sargon, Mustafa Fevzi/0000-0001-6360-6008
dc.description.abstractObjectives: The relative benefits of strategic leukofiltration on polymer-coated and low-dose heparin protocol on heparin-coated circuits were studied across EuroSCORE patient risk strata for three different cohorts. Methods: In a prospective, randomized study, 270 patients undergoing coronary artery bypass grafting were allocated into three groups (n = 90): Group 1 - polymethoxyethylacrylate-coated circuits + leukocyte filters; Group 2 - polypeptide-based heparin-bonded circuits with reduced heparinization; and Group 3 - Control: uncoated circuits. Each group was further divided into three subgroups (n = 30), with respect to low- (EuroSCORE 0-2), medium- (3-5), and high- (6+) risk patients. Blood samples were collected at T1: following induction of anesthesia; T2: following heparin administration; T3: 15 min after CPB; T4: before cessation of CPB; T5: 15 min after protamine reversal; and T6: ICU. Results: In high-risk cohorts, leukocyte counts demonstrated significant differences at T4 and T5 in Group 1, and at T4 in Group 2. Platelet counts were preserved significantly better at T4 and T5 in both groups (p < 0.05 versus control). Serum IL-2 and C3a levels were significantly lower at T3, T4 and T5 in Group 1, and T4 and T5 in Group 2 (p < 0.05). Postoperative bleeding, respiratory support time and incidence of atrial fibrillation were lower in the study groups versus control. Cell counts on filter mesh and heparin-coated fibers/ circuits were significantly higher in the high-risk cohorts versus uncoated fibers. Phagocytic capacity increased on filter mesh, especially in high-risk specimens. SEM evaluation demonstrated better preserved coated circuits. Conclusion: Leukofiltration and coating reduced platelet adhesion, protein adsorption, atrial fibrillation and reduced heparinization acted via modulation of systemic inflammatory response in high-risk groups.en_US
dc.description.sponsorshipAmer Acad Cardiovasc Perfusen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1177/0267659106070507
dc.identifier.endpage342en_US
dc.identifier.issn0267-6591
dc.identifier.issue6en_US
dc.identifier.pmid17312857
dc.identifier.scopus2-s2.0-33846890688
dc.identifier.scopusqualityQ1
dc.identifier.startpage329en_US
dc.identifier.urihttps://doi.org/10.1177/0267659106070507
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3666
dc.identifier.volume21en_US
dc.identifier.wosWOS:000244163000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofPerfusion-Uk
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleComparison of polymethoxyethylacrylate-coated circuits with leukocyte filtration and reduced heparinization protocol on heparin-bonded circuits in different risk cohortsen_US
dc.typeArticle

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