The effects of low-high doses of dexmedetomidine on erythrocyte deformability in rats

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dc.contributor.authorOzturk, L.
dc.contributor.authorArslan, M.
dc.contributor.authorComu, F. M.
dc.date.accessioned2020-06-25T18:06:48Z
dc.date.available2020-06-25T18:06:48Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractBackground: Dexmedetomidine is an anesthetic agent frequently used for sedation, intensive care units, and general anesthesia. The purpose of our study was to investigate the effect of two different doses of dexmedetomidine on erythrocyte deformability in rats. Materials and methods: The study was performed on 21 male rats, with 7 rats in each study group and the control group. The rats in the study groups were administered dexmedetomidine (low dose 5 mu g.kg(-1), high dose 10 mu g.kg(-1)) intraperitoneally, and the rats in the control group were administered physiological saline. Erythrocyte packs were prepared using heparinized total blood samples. Deformability measurements were done by erythrocyte suspensions in phosphate buffered saline (PBS) buffer. A constant flow filtrometer system was used to measure erythrocyte deformability, and the relative resistance was calculated. Results: Use of a high dose dexmedetomidine resulted in an increase in relative resistance, which is an indicator for erythrocyte deformability in control rats (p=0.014). Conclusions: High dose dexmedetomidine via negative change in erythrocyte deformability may cause a functional deterioration in blood flow and tissue perfusion. Our results showed that low dose dexmedetomidine protects erythrocyte deformability better than the high dose (Fig. 1, Ref. 23). Full Text in PDF www.elis.sk.en_US
dc.identifier.citationOzturk, L., Arslan, M., & Comu, F. M. (2012). The effects of low-high doses of dexmedetomidine on erythrocyte deformability in rats. Bratislavske lekarske listy, 113(6), 347–349.en_US
dc.identifier.doi10.4149/BLL_2012_078
dc.identifier.endpage349en_US
dc.identifier.issn0006-9248
dc.identifier.issue6en_US
dc.identifier.pmid22693969
dc.identifier.scopus2-s2.0-84864251243
dc.identifier.scopusqualityQ2
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2012_078
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5362
dc.identifier.volume113en_US
dc.identifier.wosWOS:000305723300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectalpha(2) agonisten_US
dc.subjectdexmedetomidineen_US
dc.subjectraten_US
dc.titleThe effects of low-high doses of dexmedetomidine on erythrocyte deformability in ratsen_US
dc.typeArticle

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