β2 Adrenoceptor (ADRB2) Pharmacogenetics and Cardiovascular Phenotypes during Laryngoscopy and Tracheal Intubation

Basit Öğe Kaydı
dc.contributor.authorKaymak, Çetin
dc.contributor.authorKocabaş, Neslihan A.
dc.contributor.authorDurmaz, Emre
dc.contributor.authorÖztuna, Deya
dc.date.accessioned2020-06-25T15:13:40Z
dc.date.available2020-06-25T15:13:40Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPharmacogenetics is the study of genetic variations that cause a variable drug response characterized by alteration in drug metabolism or in pharmacodynamics. The polymorphisms in genes encoding receptors relevant to treatment cause variation in sensitivity to many drugs. ?2 Adrenoceptor genetic variation contributes to regulation of blood pressure and hemodynamic changes by mediating peripheral vasodilatation. Laryngoscopy and tracheal intubation associated with hemodynamic changes. Although there are four nonsynomic single-nucleotide polymorphisms (SNPs) of ?2 adrenoceptor gene, codon 16 (Arg16Gly) and codon 27 (Gln27Glu) SNPs are both common and functionally important. In this paper, the authors investigated the ?2 adrenoceptor Gly16 and Glu27 SNPs in response to drugs relevant to anesthesia and how these SNPs impacted upon the cardiovascular phenotypes. The authors measured arterial systolic and diastolic blood pressure, heart rate, and rate-pressure product before induction of anesthesia and 1 min following laryngoscopy and tracheal intubation. Genomic DNA was amplified and genotyped using allele-specific polymerase chain reaction (ASPCR) and restriction fragment length polymorphism (RFLP) assays, respectively. When the authors compared hemodynamic results according to genotypes, the patients with Gln homozygote allele at codon 27 exhibited significant increase of heart rate than patients with Glu allele after laryngoscope and tracheal intubation. Copyright © American College of Toxicology.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/10915810600959519
dc.identifier.endpage449en_US
dc.identifier.issn10915818
dc.identifier.issue6en_US
dc.identifier.pmid17132602
dc.identifier.scopus2-s2.0-33845358698
dc.identifier.scopusqualityQ3
dc.identifier.startpage443en_US
dc.identifier.urihttps://doi.org/10.1080/10915810600959519
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1887
dc.identifier.volume25en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofInternational Journal of Toxicology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject?2 Adrenoceptoren_US
dc.subjectCardiovascular Phenotypeen_US
dc.subjectLaryngoscopyen_US
dc.subjectPharmacogeneticsen_US
dc.subjectTracheal Intubationen_US
dc.titleβ2 Adrenoceptor (ADRB2) Pharmacogenetics and Cardiovascular Phenotypes during Laryngoscopy and Tracheal Intubationen_US
dc.typeArticle

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