Effects of statin treatment on serum sex steroids levels and autonomic and erectile function

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dc.contributor.authorDogru, M. Tolga
dc.contributor.authorBasar, M. Murad
dc.contributor.authorSimsek, Ali
dc.contributor.authorYuvanc, Ercan
dc.contributor.authorGuneri, Mahmut
dc.contributor.authorEbinc, Haksun
dc.contributor.authorBatislam, Ertan
dc.date.accessioned2020-06-25T17:44:48Z
dc.date.available2020-06-25T17:44:48Z
dc.date.issued2008
dc.descriptionBatislam, Ertan/0000-0002-7493-4573
dc.description.abstractOBJECTIVES To investigate the effect of statin treatment on serum sex steroid levels, heart rate variability, erectile function, and libido in patients with hyperlipidemia. METHODS A total of 74 patients (mean age 44.7 +/- 7.1 years) with hyperlipidemia were enrolled into this study. After a cardiac examination, the serum lipid levels were measured, and the 24-hour Holter monitoring, heart rate variability, and autonomic test results were also evaluated. Erectile function was assessed using the International Index of Erectile Function (IIEF) questionnaire. Later, atorvastatin 40 mg/day was initiated in all patients and used for the subsequent 12 months. All diagnostic tests (cardiac, biochemical, and autonomic and the IIEF questionnaire) were performed again at 6 and 12 months of follow-Lip. RESULTS A statistically significant decrease was found in the serum lipid levels at 6 months (P<0.05). In contrast, the average IIEF scores (24.7 +/- 6.4 at baseline) had increased to 25.0 +/- 4.9 and 26.1 +/- 5.9 at 6 and 12 months of follow-up, respectively. Although the parasympathetic activities increased and sympathetic activities decreased with atorvastatin treatment, these changes were not statistically significant (P>0.05). In paired comparison, significant differences were found among the IIEF scores of the three periods (P = 0.013). The difference was more evident after 6 months of treatment (IIEF1vs2 = 0.475; IIEF1vs3 = 0.027; IIEF2vs3 = 0.012). CONCLUSIONS Although improvement in the lipid profile occurred early during the statin treatment, restoration of erectile function appeared later, which Could be attributed to the restoration of endothelial functions by lowered serum lipid levels.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.urology.2007.11.059
dc.identifier.endpage707en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue4en_US
dc.identifier.pmid18387399
dc.identifier.scopus2-s2.0-41149091861
dc.identifier.scopusqualityQ2
dc.identifier.startpage703en_US
dc.identifier.urihttps://doi.org10.1016/j.urology.2007.11.059
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4201
dc.identifier.volume71en_US
dc.identifier.wosWOS:000254813800038
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffects of statin treatment on serum sex steroids levels and autonomic and erectile functionen_US
dc.typeArticle

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