Chondroitin sulfate-coated polyhydroxyethyl methacrylate membrane prevents adhesion in full-thickness tendon tears of rabbits

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dc.contributor.authorGüdemez, E.
dc.contributor.authorEksioglu, F.
dc.contributor.authorKorkusuz, P.
dc.contributor.authorAsan, E.
dc.contributor.authorGürsel, I.
dc.contributor.authorHasirci, V.
dc.date.accessioned2020-06-25T17:35:06Z
dc.date.available2020-06-25T17:35:06Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.descriptionKORKUSUZ, PETEK/0000-0002-7553-3915
dc.description.abstractPolyhydroxyethyl methacrylate (pHEMA) membranes coated on one side with chondroitin sulfate (CS) were used to block adhesion physically and to reduce friction between healing flexor tendons and the surrounding tissue in rabbit forepaws after surgical repair. Digits with pHEMA-only, standard tendon sheath repair, and with no sheath repair were the controls. Over 12 weeks the CS-coated membranes were evaluated for joint flexion, adhesion limitation, and tendon healing progress. The membranes initially allowed for better flexion (i.e, for 6 weeks), but their relative superior effectiveness faded afterward. Histology showed that adhesions were less severe and healing was better in the CS-pHEMA membranes at 3 and 6 weeks. If further studies determine precise amounts or thicknesses of CS coats that will maximize its healing properties, CS-pHEMA should prove useful in clinical settings in which restoration of tendon sheath integrity with a minimum of adhesions is not possible. Copyright (C) 2002 by the American Society for Surgery of the Hand.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1053/jhsu.2002.31161
dc.identifier.endpage306en_US
dc.identifier.issn0363-5023
dc.identifier.issn1531-6564
dc.identifier.issue2en_US
dc.identifier.pmid11901389
dc.identifier.scopus2-s2.0-0036128840
dc.identifier.scopusqualityQ2
dc.identifier.startpage293en_US
dc.identifier.urihttps://doi.org/10.1053/jhsu.2002.31161
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3021
dc.identifier.volume27Aen_US
dc.identifier.wosWOS:000174437300013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Hand Surgery-American Volume
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttendon injuriesen_US
dc.subjectadhesionen_US
dc.subjectpolyhydroxyethyl methacrylate (pHEMA)en_US
dc.subjectchondroitin sulfateen_US
dc.subjectbiomaterialsen_US
dc.titleChondroitin sulfate-coated polyhydroxyethyl methacrylate membrane prevents adhesion in full-thickness tendon tears of rabbitsen_US
dc.typeArticle

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