Effects of repeated sevoflurane anesthesia on renal function: An animal study

Basit Öğe Kaydı
dc.contributor.authorKaymak Ç.
dc.contributor.authorBaşar H.
dc.contributor.authorKurtipek Ö.
dc.contributor.authorŞentürk Z.
dc.contributor.authorBomba F.
dc.contributor.authorSürücü S.
dc.contributor.authorErdemli E.
dc.date.accessioned2020-06-25T15:13:27Z
dc.date.available2020-06-25T15:13:27Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: The effect of repeated administrations of sevoflurane in rats was evaluated with free inorganic plasma fluoride concentrations and the effect of sevoflurane on the kidneys. Methods: Thirty-five rats were divided into two groups. The control group consisted of 7 rats, and the sevoflurane group consisted of 28 rats. The sevoflurane group was divided equally into 4 subgroups according to the time of sacrifice (S1, S3, S5, S10). All rats in the sevoflurane group were administered 3% sevoflurane for 30 minutes for 5 days. After anesthesia, the rats were sacrificed at the end of the 1st, 3rd and 5th days. The other 7 were kept without anesthesia for 5 days and they were sacrificed at the end of the 10th day. Plasma inorganic fluoride concentrations were measured by ion-selective electrode methods in aspirated heart blood samples. Renal biopsies were taken just after sacrifice and the renal histopathologic effects of sevoflurane were investigated under light and transmission electron microscopy (TEM). Results: Plasma fluoride concentrations were significantly different between the sevoflurane and control groups. However, there was no statistical difference between the sevoflurane subgroups. Plasma BUN levels did not differ between the control and sevoflurane groups, except on the 10th day. Ultrastructurally, the sevoflurane subgroups (S-3, S-5, S-10) showed significant tubular histopathologic changes compared to the control group. However, these changes showed a significant regression on the 10th day. Conclusion: Repeated sevoflurane administration is a safe procedure since histopathological changes showed significant regression.en_US
dc.identifier.citationKaymak, Ç., Başar, H., Kurtipek, Ö., Şentürk, Z., Bomba, F., Sürücü, S., Erdemli, E., Ünal, N. (2004). Effects of repeated sevoflurane anesthesia on renal function: An animal study. Gazi Medical Journal, 15(1), 1 - 6.en_US
dc.identifier.endpage6en_US
dc.identifier.issn1300056X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-16444366502
dc.identifier.scopusqualityQ4
dc.identifier.startpage1en_US
dc.identifier.trdizinid47965
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1800
dc.identifier.volume15en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFluorideen_US
dc.subjectInhalation Anesthesiaen_US
dc.subjectRenal Toxicityen_US
dc.subjectSevofluraneen_US
dc.titleEffects of repeated sevoflurane anesthesia on renal function: An animal studyen_US
dc.typeArticle

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