Alginate-based bio-nanocomposite reinforced with poly(2-hydroxypropyl methacrylamide) and magnetite graphene oxide for delivery of etoposide and photothermal therapy

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dc.contributor.authorIsiklan, Nuran
dc.contributor.authorGeyik, Gulcan
dc.contributor.authorGuncum, Enes
dc.date.accessioned2025-01-21T16:35:30Z
dc.date.available2025-01-21T16:35:30Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractRecently, bio-nanocomposite nanogels/hydrogels composed of natural polymers and carbon-based nano- materials are attracting increasing attention in the fields of nanomedicine and bioengineering due to their unique properties. In this study, we propose the creation of an innovative multifunctional bio-nanocomposite based on alginate graft copolymer with poly(2-hydroxypropyl methacrylamide) (SA-g-PHPM) and magnetite graphene oxide (mGO) loaded with etoposide (EPS) for drug delivery and photothermal therapy (PTT). The SA-g-PHPM/ mGO bio-nanocomposite was synthesized using an emulsion method and exhibited favorable physicochemical properties. The structural functionalities and surface morphology of the SA-g-PHPM/mGO bio-nanocomposite were comprehensively characterized using spectroscopic techniques, including FT-IR, XRD, UV, DLS, TEM/FESEM, and AFM analyses. Under near-infrared (NIR) irradiation (808 nm, 1 Wcm-(2), 10 min), the SA-g-PHPM/ mGO bio-nanocomposite demonstrated the ability to effectively induce a temperature increase exceeding 29 degrees C. Additionally, exposure to NIR light and magnetic field led to an increased release of EPS whereas an increment in percentage of mGO caused a decreased EPS release. Notably, the synergistic effects of chemotherapy, light-triggered drug release, and PTT collectively contributed to a significant enhancement in lung cancer (H1299) cell death. In conclusion, our findings suggest that the developed SA-g-PHPM/mGO/EPS bionanocomposite serves as an efficient vehicle for multimodal therapy in lung cancer.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kimath;rimath;kkale University [2021/066]
dc.description.sponsorshipThe authors express their appreciation to the Scientific Research Projects Coordination Unit of K & imath;r & imath;kkale University for their financial support [Project number: 2021/066]. We also extend our gratitude to Deva Holding A.S,(Turkey) for kindly supplying the etoposide used in this study.
dc.identifier.doi10.1016/j.mtchem.2024.102323
dc.identifier.issn2468-5194
dc.identifier.scopus2-s2.0-85204494554
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.mtchem.2024.102323
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24144
dc.identifier.volume41
dc.identifier.wosWOS:001321998800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofMaterials Today Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAlginate graft copolymer; Magnetite graphene oxide; Multi-stimuli-responsive bio-nanocomposite; Etoposide; PTT
dc.titleAlginate-based bio-nanocomposite reinforced with poly(2-hydroxypropyl methacrylamide) and magnetite graphene oxide for delivery of etoposide and photothermal therapy
dc.typeArticle

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