In vitro genotoxic effects of ZnO nanomaterials in human peripheral lymphocytes

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dc.contributor.authorGumus, Duygu
dc.contributor.authorBerber, Ahmet Ali
dc.contributor.authorAda, Kezban
dc.contributor.authorAksoy, Huseyin
dc.date.accessioned2020-06-25T18:12:17Z
dc.date.available2020-06-25T18:12:17Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, possible genotoxic effects of zinc oxide (ZnO) nanoparticles were investigated in cultured human peripheral lymphocytes by using chromosome aberrations and micronucleus assays (MN). For this purpose, the cells were treated with ZnO (1, 2, 5, 10, 15 and 20 mu g/mL) for 24 and 48 h. In this research, four types of chromosome aberrations were observed as chromatid and chromosome breaks, fragment and dicentric chromosomes. ZnO induced significant increase of the ratio of chromosomal aberrations as well as percentage of abnormal cells at concentrations of 1, 5, 10 and 20 mu g/mL in 24 h treatments. In 48 h treatments, while ZnO nanomaterials induced significant increase of the percentage of abnormal cells only at a concentration of 10 mu g/mL, and of chromosome aberration per cell in comparison to the control at concentrations of 5 and 10 mu g/mL. On the other hand, this material significantly increased the micronuclei frequency (MN) at concentrations of 10 and 15 mu g/mL in comparison to the control. Cytokinesis-block proliferation index was not affected by ZnO treatments. It also decreased the mitotic index in all concentrations at 24 h but not at 48 h. The present results indicate that ZnO nanoparticles are clastogenic, mutagenic and cytotoxic to human lymphocytes in vitro at specific concentrations and time periods.en_US
dc.description.sponsorshipSakarya UniversitySakarya University [2009-50-01-007]en_US
dc.description.sponsorshipThe authors thanks to the Sakarya University for founding this research (grant 2009-50-01-007).en_US
dc.identifier.citationGümüş, D., Berber, A. A., Ada, K., & Aksoy, H. (2014). In vitro genotoxic effects of ZnO nanomaterials in human peripheral lymphocytes. Cytotechnology, 66(2), 317–325.en_US
dc.identifier.doi10.1007/s10616-013-9575-1
dc.identifier.endpage325en_US
dc.identifier.issn0920-9069
dc.identifier.issn1573-0778
dc.identifier.issue2en_US
dc.identifier.pmid23784729
dc.identifier.scopus2-s2.0-84894348200
dc.identifier.scopusqualityQ3
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.1007/s10616-013-9575-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5846
dc.identifier.volume66en_US
dc.identifier.wosWOS:000334175000013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectZnOen_US
dc.subjectNanomaterialen_US
dc.subjectChromosome aberrationen_US
dc.subjectMicronucleien_US
dc.subjectHuman peripheral lymphocytesen_US
dc.titleIn vitro genotoxic effects of ZnO nanomaterials in human peripheral lymphocytesen_US
dc.typeArticle

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