Diffusion tensor imaging in children and adolescents with tuberous sclerosis

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dc.contributor.authorKaradağ, Demet
dc.contributor.authorMentzel, Hans J.
dc.contributor.authorGullmar, Daniel
dc.contributor.authorRating, Tina
dc.contributor.authorLobel, Ulrike
dc.contributor.authorBrandl, Ulrich
dc.contributor.authorKaiser, Werner A.
dc.date.accessioned2020-06-25T17:40:24Z
dc.date.available2020-06-25T17:40:24Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionReichenbach, Jurgen R./0000-0002-2640-0630; Guellmar, Daniel/0000-0001-8693-8099; Warfield, Simon/0000-0002-7659-3880
dc.description.abstractBackground: Tuberous sclerosis (TS) is characterised by benign hamartomatous lesions in many organs. Diffusion tensor imaging (DTI) can detect microstructural changes in pathological processes. Objective: To determine apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps in children with TS and to investigate the diffusion properties in cortical tubers, white-matter lesions, perilesional white matter, and contralateral normal-appearing white matter, and to compare the results with ADC and FA maps of normal age- and sex-matched volunteers. Materials and methods: Seven children and adolescents (age range 2-20 years) suffering from TS were included. MRI was performed on a 1.5-T scanner using a transmit/receive coil with T1-W and T2-W spin-echo and FLAIR sequences. DT images were acquired by using a single-shot echo-planar pulse sequence. Diffusion gradients were applied in six different directions with a b value of 1,000 s/mm(2). Results: ADC was higher in cortical tubers than in the corresponding cortical location of controls. ADC values were higher and FA values were lower in white-matter lesions and perilesional white matter than in both the contralateral normal-appearing white matter of patients and in controls. There were no significant differences for both ADC and FA values in the normal-appearing white matter of patients with TS compared to controls. Conclusions: DTI provides important information about cortical tubers, white-matter abnormalities, and perilesional white matter in patients with TS.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00247-005-1504-9
dc.identifier.endpage983en_US
dc.identifier.issn0301-0449
dc.identifier.issn1432-1998
dc.identifier.issue10en_US
dc.identifier.pmid16170442
dc.identifier.startpage980en_US
dc.identifier.urihttps://doi.org/10.1007/s00247-005-1504-9
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3425
dc.identifier.volume35en_US
dc.identifier.wosWOS:000231949700004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectapparent diffusion coefficienten_US
dc.subjectfractional anisotropyen_US
dc.subjectMRIen_US
dc.subjecttuberous sclerosisen_US
dc.titleDiffusion tensor imaging in children and adolescents with tuberous sclerosisen_US
dc.typeArticle

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