Effects of the general anaesthetic agent, propofol, on erythrocyte deformability

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dc.contributor.authorArslan, Mustafa
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorIsik, Berrin
dc.contributor.authorUnal, Yusuf
dc.contributor.authorCekmen, Nedim
dc.contributor.authorKurtipek, Omer
dc.date.accessioned2020-06-25T17:51:21Z
dc.date.available2020-06-25T17:51:21Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractObjectives: Propofol is an anesthetic agent frequently used for sedation and general anesthesia. The purpose of our study was to investigate the effect of propofol, a general anesthetic, on erythrocyte deformability in rats. Methodology: The study was performed on 20 male and 20 female rats, with 10 rats in each study group and 10 rats in each control group. The rats in the study group were administered propofol (150 mg.kg(-1)) intraperitoneally, and the rats in the control group were administered SF. Erythrocyte packs were prepared using heparinized total blood samples. Deformability measurements were done by erythrocyte suspensions in PBS buffer. A constant flow filtrometer system was used to measure erythrocyte deformability, and the relative resistance was calculated. Results: The use of propofol resulted in the increase in the relative resistance, which is an indicator for the erythrocyte deformability in both male and female rats (p=0.002, p=0.042, respectively). Conclusion: A negative change in the erythrocyte deformability may cause a functional deterioration in blood flow and tissue perfusion (Fig. 1, Ref. 23). Full Text (Free, PDF) www.bmj.sk.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage128en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue3en_US
dc.identifier.pmid20437820
dc.identifier.scopus2-s2.0-77952966126
dc.identifier.scopusqualityQ2
dc.identifier.startpage126en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4822
dc.identifier.volume111en_US
dc.identifier.wosWOS:000276730200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectpropofolen_US
dc.subjectraten_US
dc.titleEffects of the general anaesthetic agent, propofol, on erythrocyte deformabilityen_US
dc.typeArticle

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