Ischemia-reperfusion injury of rabbit ovary and protective effect of trapidil: an experimental study

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dc.contributor.authorSomuncu, Salih
dc.contributor.authorCakmak, Murat
dc.contributor.authorDikmen, Gunnur
dc.contributor.authorAkman, Huelya
dc.contributor.authorKaya, Murat
dc.date.accessioned2020-06-25T17:44:53Z
dc.date.available2020-06-25T17:44:53Z
dc.date.issued2008
dc.description.abstractWe aimed to detect the protective effect of trapidil in ischemia-reperfusion (IR) injury due to ovarian torsion and detorsion. Thirty-two pubertal New Zealand albino rabbits were used. Adnexal torsion was created by rotating the left adnexa including the tubal and ovarian vessels in a 360 clockwise direction. Adnexal detorsion was done by untwisting the adnexa. In the IR group, left oopherectomy was performed after 3 h of adnexal torsion and 3 h of adnexal detorsion. In the study group, a 3-h adnexal torsion was performed and trapidil was administered intraperitoneally as a single dose of 40 mg/kg, 1 h before detorsion. The left oopherectomy was performed after a 3-h adnexal detorsion. In the sham group, sham operation was performed followed by left oopherectomy. In the control group, normal ovarian tissue was evaluated. Catalase, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels of ovarian tissue were determined for each group. The values of SOD and GSH-Px activities in the IR group were significantly decreased (P < 0.05). In addition, the MDA level was significantly higher in the IR group (P < 0.01). The trapidil-administered group showed significant increase in the levels of GSH-Px (P < 0.05), catalase (P < 0.05), SOD (P < 0.05), and decreased MDA levels (P < 0.05) compared to those in the IR group. The study has shown that trapidil treatment prevents ischemia induced oxidative damage in the ovarian tissues of rabbits.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00383-007-2079-3
dc.identifier.endpage318en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue3en_US
dc.identifier.pmid18060415
dc.identifier.scopus2-s2.0-43149092889
dc.identifier.scopusqualityQ2
dc.identifier.startpage315en_US
dc.identifier.urihttps://doi.org10.1007/s00383-007-2079-3
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4218
dc.identifier.volume24en_US
dc.identifier.wosWOS:000253483600013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectovarian torsion-detorsionen_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjecttrapidilen_US
dc.subjectfree oxygen radicalsen_US
dc.titleIschemia-reperfusion injury of rabbit ovary and protective effect of trapidil: an experimental studyen_US
dc.typeArticle

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