The role of pomegranate seed oil on kidney and lung tissues in the treatment of sepsis: animal pre-clinical research

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridYavuz, Aydin/0000-0003-0091-7997
dc.authoridBOZOK, Ummu Gulsen/0000-0002-2016-7305
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.contributor.authorArslan, Mustafa
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorBozok, Ummu Gulsen
dc.contributor.authorErgoruen, Aydan Iremnur
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorYavuz, Aydin
dc.contributor.authorKavutcu, Mustafa
dc.date.accessioned2025-01-21T16:55:19Z
dc.date.available2025-01-21T16:55:19Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: Sepsis is a common disease with a high mortality. Decreasing the speed is possible with early and intensive therapy. However, most medicines have been tested, but none has proven effective. Therefore, the study aimed to discover the protective and therapeutic effects of pomegranate seed oil (PSO). Methods: The cecal ligation puncture (CLP) method was used to induce sepsis. The experimental procedure was started with the animals divided haphazardly into four groups: control (C), sepsis (CLP), CLP + low dose PSO (CLP + LD), and CLP + high dose PSO (CLP + HD). First, the cecum was filled with feces. The full cecum was tied under the ileocecal valve for ligation and punctured. At 1 hour after CLP, 0.32 mg/kg and 0.64 mg/kg of PSO were administered. 24 hours after, lung and kidney specimens were collected. Results: Neutrophil infiltration/aggregation and alveolar wall thickness decreased in lung with PSO groups compared with the CLP. The findings for overall lung injury were similar. In renal, all parameters were increased in the CLP compared with C, except for vascular vacuolization and hypertrophy. According to the CLP, all parameters were significantly lower in CLP + HD. Furthermore, glomerular vacuolization, degeneration, and necrosis of tubular cell, dilatation of bowman space, and tubular hyaline cylinders reduced CLP + LD versus CLP. Thiobarbituric acid-reactive substances decreased in lung, with the PSO groups. In addition, superoxide dismutase increased in PSO groups versus CLP. Conclusions: We conclude that the high-dose PSO is especially effective in treating sepsis.
dc.identifier.doi10.3855/jidc.17720
dc.identifier.endpage1797
dc.identifier.issn1972-2680
dc.identifier.issue12
dc.identifier.pmid38252732
dc.identifier.scopus2-s2.0-85183243830
dc.identifier.scopusqualityQ2
dc.identifier.startpage1791
dc.identifier.urihttps://doi.org/10.3855/jidc.17720
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25757
dc.identifier.volume17
dc.identifier.wosWOS:001165532000015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJ Infection Developing Countries
dc.relation.ispartofJournal of Infection In Developing Countries
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectcecum; ligation; multiple organ failure; perforation; pomegranate; sepsis
dc.titleThe role of pomegranate seed oil on kidney and lung tissues in the treatment of sepsis: animal pre-clinical research
dc.typeArticle

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