Cytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical study

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dc.contributor.authorKarahan, S.
dc.contributor.authorYarim, M.
dc.contributor.authorHarada, N.
dc.date.accessioned2020-06-25T17:48:05Z
dc.date.available2020-06-25T17:48:05Z
dc.date.issued2008
dc.description/0000-0002-0636-4214
dc.description.abstractThe enzyme cytochrome P450 aromatase is responsible for conversion of androgens to estrogens. Estrogens have been implicated in neurophysiology and neuropathology. The present study investigated the presence of aromatase immuno reactivity in the temporal, parietal and occipital cortices, olfactory bulb, cerebellum, and choroid plexus of the normal dog. Aromatase immunoreactivity was localized exclusively in neurons in the cortices and olfactory bulb. Immunoreactivity was also present in a small number of astrocytes in the substantia alba of the cerebellum. In the cortical regions, immunoreactive neurons, morphologically identified as pyramidal cells, were found throughout Layer 11 down to Layer VI, but not all pyramidal neurons were immunoreactive. In the olfactory bulb, immunoreactive neurons were mainly observed in mitral cells and inner granular cell layers. In the cerebellum, immunoreactivity was present in neurons of the deep cerebellar nuclei and in some neurons of the molecular and granular cell layers. Immunoreactivity was also present in endothelial cells of the subarachnoid vessels and those adjacent to ventricles in the cortex. The presence of well defined cytoplasmic aromatase immunoreactivity in neurons, some astrocytes, and endothelial cells suggests estrogen involvement in CNS physiology and function in the dog. The presence of aromatase in ependymal cells lining cerebral ventricles and choroid epithelial cells suggests that these cells may be partially responsible for estrogen concentration in the cerebrospinal fluid.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage352en_US
dc.identifier.issn1505-1773
dc.identifier.issue4en_US
dc.identifier.pmid19227133
dc.identifier.scopus2-s2.0-57849135151
dc.identifier.scopusqualityQ3
dc.identifier.startpage347en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4291
dc.identifier.volume11en_US
dc.identifier.wosWOS:000262037400009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPolish Acad Sciences, Committee Veterinary Sciencesen_US
dc.relation.ispartofPolish Journal Of Veterinary Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaromataseen_US
dc.subjectestrogenen_US
dc.subjectneurosteroidsen_US
dc.subjectimmunohistochemistryen_US
dc.subjectdogen_US
dc.titleCytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical studyen_US
dc.typeArticle

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