Histamine 1 Receptor Antagonist in Symptomatic Treatment of Renal Colic Accompanied by Nausea: Two Birds With One Stone?

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dc.contributor.authorYılmaz, Erdal
dc.contributor.authorBatislam, Ertan
dc.contributor.authorDeniz, Turgut
dc.contributor.authorYuvanç, Ercan
dc.date.accessioned2020-06-25T17:49:01Z
dc.date.available2020-06-25T17:49:01Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionBatislam, Ertan/0000-0002-7493-4573
dc.description.abstractOBJECTIVES The pain-relieving efficacy of antagonists of histamine I (HI) receptors that are widely found in the ureter and that cause contractions in renal colic was presented in comparison with a placebo. METHODS Eighty-six patients who presented to the emergency service because of renal colic accompanied by nausea, and who had urinary system stones detected were included in the study. The patients were separated into 2 groups by double-blind, random assignment. The 45 patients in group 1 received 50 mg intramuscular (IM) dimenhydrinate. The 41 patients in group 2 received 2 mL IM saline solution as a placebo. The visual analogous scale (VAS) values were detected at referral of the patients and at 10, 20, and 30 minutes of therapy to detect the pain intensity. Verbal descriptive scale (VDS) was used for evaluation of nausea and vomiting before and after the therapy. RESULTS VAS values were statistically quite low in group 1 at 10, 20, and 30 minutes of therapy. VDS scores were also statistically significantly low in group 1 at 30 minutes of treatment. CONCLUSIONS Dimenhydrinate, which is an ethanolamine group H1 receptor blocker, appeared to be effective compared with the placebo in relieving renal colic pain and nausea and vomiting symptoms in patients. Comparative studies with other analgesics will be useful for determining how to use this agent for analgesic purposes in renal colic. UROLOGY 73: 32-36, 2009. (C) 2009 Elsevier Inc.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.urology.2008.08.494
dc.identifier.endpage36en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue1en_US
dc.identifier.pmid18849063
dc.identifier.scopus2-s2.0-57849133461
dc.identifier.scopusqualityQ2
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2008.08.494
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4617
dc.identifier.volume73en_US
dc.identifier.wosWOS:000262379700011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleHistamine 1 Receptor Antagonist in Symptomatic Treatment of Renal Colic Accompanied by Nausea: Two Birds With One Stone?en_US
dc.typeArticle

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