The effect of cerium oxide on lung injury following lower extremity ischemia-reperfusion injury in rats under desflurane anesthesia

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.authoridgunes, isin/0000-0001-6438-8153
dc.authoridKARA, HALIL/0000-0002-7557-7897
dc.contributor.authorOzdemirkan, Aycan
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorGunes, Isin
dc.contributor.authorArslan, Mustafa
dc.contributor.authorTuncay, Aydin
dc.contributor.authorSivgin, Volkan
dc.contributor.authorSezen, Saban C.
dc.date.accessioned2025-01-21T16:45:03Z
dc.date.available2025-01-21T16:45:03Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: To examine the effects of desflurane and cerium oxide (CO) on lung tissue following ischemia-reperfusion injury (IRI). Methods: Experiments were conducted in Gazi University Animal Laboratory, Ankara, Turkey. Thirty rats were divided into 5 groups: control (C), IRI, IRI-CO, IRI-desflurane (IRID), IRI-CO-desflurane (IRICOD). Cerium oxide was given intraperitoneally. Lower extremity IRI was induced. Desflurane was applied during IRI. Lung histopathological examinations and serum biochemical analyses were performed. Results: Serum nitric oxide (NO) and malondialdehyde (MDA) levels were higher in group IRI (p=0.006) than in group C (p=0.001). Serum MDA and NO levels were significantly lower in groups IRICO and IRICOD than in group IRI. Significantly greater alveolar wall thickening and neutrophil infiltration were recorded in group IRI than in group C. Co-administration of desflurane and CO significantly decreased alveolar wall thickening and neutrophil infiltration compared to group IRI. Total lung injury scores were significantly lower in groups IRID, IRICO, and IRICOD than in group IRI. Conclusion: Intraperitoneal CO with desflurane, reduced oxidative stress and corrected the damage in lung. Cerium oxide given before and desflurane given during IRI have been shown to have protective effects on lung damage in rats.
dc.identifier.doi10.15537/smj.2021.42.11.20210104
dc.identifier.endpage1251
dc.identifier.issn0379-5284
dc.identifier.issn1658-3175
dc.identifier.issue11
dc.identifier.pmid34732559
dc.identifier.scopus2-s2.0-85119270179
dc.identifier.scopusqualityQ2
dc.identifier.startpage1247
dc.identifier.urihttps://doi.org/10.15537/smj.2021.42.11.20210104
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25580
dc.identifier.volume42
dc.identifier.wosWOS:000715831800013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSaudi Med J
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectcerium; desflurane; ischemia-reperfusion injury; lung injury
dc.titleThe effect of cerium oxide on lung injury following lower extremity ischemia-reperfusion injury in rats under desflurane anesthesia
dc.typeArticle

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