The Genotoxic Effect of Nasal Steroids on Human Nasal Septal Mucosa and Cartilage Cells In Vitro

Basit Öğe Kaydı
dc.authoridVURAL, OMER/0000-0001-7157-0850
dc.authoridBuyuklu, Fuat/0000-0003-1528-0036
dc.authoridTurkoglu Babakurban, Seda/0000-0001-5067-4044
dc.contributor.authorBabakurban, Seda Turkoglu
dc.contributor.authorVural, Omer
dc.contributor.authorKasap, Yesim Korkmaz
dc.contributor.authorHizal, Evren
dc.contributor.authorYurtcu, Erkan
dc.contributor.authorBuyuklu, Adnan Fuat
dc.date.accessioned2025-01-21T16:45:33Z
dc.date.available2025-01-21T16:45:33Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: To determine whether budesonide (Bud) and triamcinolone acetate (TA) cause DNA fractures in the nasal mucosa and septal cartilage cells through examinations using the comet assay technique. Study design: Prospective, controlled experimental study. Setting: University hospital. Methods: Septal mucosal epithelial and cartilage tissue samples were taken from 9 patients. Cell cultures were prepared from these samples. Then, budesonide and triamcinolone acetate active ingredients at 2 different doses of 0.2 and 10 mu M were separately applied to the cell cultures formed from both tissues of each patient, except the control cell culture, for 7 days in one group and 14 days in one group. After the applications, genotoxic damage was scored with the comet assay technique and the groups were compared. Results: In both the budesonide and triamcinolone acetate groups, the comet scores at low and high doses, on the 7th and 14th days were found to be significantly higher in both cartilage and epithelial tissue than in the control group. Conclusion: The study results showed that budesonide and triamcinolone acetate lead to a significantly high rate of genotoxic damage in both epithelial tissue and cartilage tissue.
dc.description.sponsorshipResearch Council of the Faculty of Medicine, Baskent University
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study received financial support from the Research Council of the Faculty of Medicine, Baskent University
dc.identifier.doi10.1177/00034894221099355
dc.identifier.endpage503
dc.identifier.issn0003-4894
dc.identifier.issn1943-572X
dc.identifier.issue5
dc.identifier.pmid35695134
dc.identifier.scopus2-s2.0-85131749748
dc.identifier.scopusqualityQ2
dc.identifier.startpage497
dc.identifier.urihttps://doi.org/10.1177/00034894221099355
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25674
dc.identifier.volume132
dc.identifier.wosWOS:000811589000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofAnnals of Otology Rhinology and Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectbudesonide; comet assay; DNA damage; triamcinolone acetate; topical steroid
dc.titleThe Genotoxic Effect of Nasal Steroids on Human Nasal Septal Mucosa and Cartilage Cells In Vitro
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu