Aromatase expression in the cerebellum of the dog infected with canine distemper virus

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dc.contributor.authorYarım, Murat
dc.contributor.authorGülbahar, Mustafa Yavuz
dc.contributor.authorGüvenç, Tolga
dc.contributor.authorKarahan, Siyami
dc.contributor.authorHarada, Nobuhiro
dc.contributor.authorKabak, Yonca Betil
dc.contributor.authorKarayiğit, Mehmet Önder
dc.date.accessioned2020-06-25T17:49:25Z
dc.date.available2020-06-25T17:49:25Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionGuvenc, Tolga/0000-0003-1468-3415; /0000-0002-0636-4214; GULBAHAR, MUSTAFA YAVUZ/0000-0001-8268-7659
dc.description.abstractAromatase is the enzyme that catalyzes the biosynthesis of estrogens. It is implicated in neuroprotection. The present study investigated aromatase expression in the cerebellum of dogs infected with canine distemper virus (CDV), a disease characterized by demyelination in the white matter of the cerebellum. The presence of CDV infection was confirmed on the basis of histopathology and immunohistochemical localization of CDV antigen in glial cells of the white matter. The number of aromatase immunoreactive astrocytes were significantly (p < 0.05) higher in CDV-infected dogs compared to control dogs. The results suggest that astrocytes respond to invasion and persistence of CDV by means of increased estrogen production. The results also suggest that the high level of estrogen expression is maintained similarly throughout all stages of the disease since the number of aromatase immunoreactive astrocytes did not vary during the different stages of CDV infection.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.2376/0005-9366-123-301
dc.identifier.endpage306en_US
dc.identifier.issn0005-9366
dc.identifier.issue7-8en_US
dc.identifier.pmid20690542
dc.identifier.scopus2-s2.0-77956629900
dc.identifier.scopusqualityQ3
dc.identifier.startpage301en_US
dc.identifier.urihttps://doi.org/10.2376/0005-9366-123-301
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4709
dc.identifier.volume123en_US
dc.identifier.wosWOS:000279747800005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSchluetersche Verlagsgesellschaft Mbh & Co Kgen_US
dc.relation.ispartofBerliner Und Munchener Tierarztliche Wochenschrift
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaromataseen_US
dc.subjectastrocytesen_US
dc.subjectcanin distemper virusen_US
dc.subjectcerebellumen_US
dc.subjectdemyelinationen_US
dc.titleAromatase expression in the cerebellum of the dog infected with canine distemper virusen_US
dc.typeArticle

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