Melatonin Protects Inner Ear Against Radiation Damage in Rats

Basit Öğe Kaydı
dc.contributor.authorKaraer, Isil
dc.contributor.authorSimsek, Gokce
dc.contributor.authorGul, Mehmet
dc.contributor.authorBahar, Leyla
dc.contributor.authorGurocak, Simay
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorNuransoy, Ayse
dc.date.accessioned2020-06-25T18:12:47Z
dc.date.available2020-06-25T18:12:47Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionBAHAR, LEYLA/0000-0002-6910-6167; SIMSEK, GOKCE/0000-0001-5281-0986; Parlakpinar, Hakan/0000-0001-9497-3468; BAHAR, LEYLA/0000-0002-6910-6167
dc.description.abstractObjectives/Hypothesis: To examine the effects of N-acetyl-5-methoxytryptamine (melatonin) on radiation-induced inner ear damage. Study Design: An experimental animal model. Methods: Forty rats were randomized into five groups, as follows: 1) melatonin and then radiotherapy group (n = 8), which received intraperitoneal (i.p.) melatonin (5 mg/kg) followed by irradiation 30 minutes later; 2) radiotherapy and then melatonin group (n = 8), which received irradiation with i.p. melatonin (5 mg/kg) 30 minutes later; 3) melatonin group (n = 8), which received i.p. melatonin (5 mg/kg); 4) radiotherapy group (n = 8), which underwent only irradiation; 5) and the control group (n = 8), which received i.p. 0.9% NaCl. The medications and irradiation were administered for 5 days. All rats underwent the distortion product otoacoustic emission (DPOAE) test before and 10 days after the experiment. The middle ears of the rats were excised, and assessment of tissue alterations in the organs of Corti, spiral ganglions, and stria vascularis were compared among the groups. Results: In the radiotherapy group, the DPOAE amplitudes at frequencies of 4000 to 6000 Hz were significantly decreased when compared with the controls. The DPOAE amplitudes both in the melatonin and then radiotherapy group and the radiotherapy and then melatonin group exhibited better values than they did in the radiotherapy group. Histopathological evidence of damage to the organs of Corti, spiral ganglions, and stria vascularis damage was markedly reduced in both these two groups when compared to the radiotherapy group. Conclusion: These results indicate that melatonin may have significant ameliorative effects on cochlear damage secondary to ionizing radiation.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/lary.25376
dc.identifier.endpageE349en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue10en_US
dc.identifier.pmid25994110
dc.identifier.scopus2-s2.0-84942821709
dc.identifier.scopusqualityQ1
dc.identifier.startpageE345en_US
dc.identifier.urihttps://doi.org/10.1002/lary.25376
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6042
dc.identifier.volume125en_US
dc.identifier.wosWOS:000363386300004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofLaryngoscope
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInner earen_US
dc.subjectmelatoninen_US
dc.subjectotoacoustic emissionen_US
dc.subjectradiotherapyen_US
dc.titleMelatonin Protects Inner Ear Against Radiation Damage in Ratsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Melatonin Protects Inner Ear Against Radiation Damage in Rats.pdf
Boyut:
301.92 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu