The relationship among asymmetric dimethylarginine (ADMA) levels, residual renal function, and left ventricular hypertrophy in continuous ambulatory peritoneal dialysis patients

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dc.contributor.authorEbinc, Fatma Ayerden
dc.contributor.authorErten, Yasemin
dc.contributor.authorEbinc, Haksun
dc.contributor.authorPasaoglu, Hatice
dc.contributor.authorDemirtas, Canan
dc.contributor.authorTacoy, Guelten
dc.contributor.authorSindel, Suekrue
dc.date.accessioned2020-06-25T17:48:05Z
dc.date.available2020-06-25T17:48:05Z
dc.date.issued2008
dc.description.abstractAsymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial-based nitric oxide synthase. Its level is increased by end stage renal disease. However, most studies showing an increase in ADMA in dialysis patients have focused on hemodialysis. Results with peritoneal dialysis patients have been more inconclusive. Recent studies suggest that ADMA may be a new cardiovascular risk factor. The aim of the present study was to evaluate the relationship between ADMA levels, residual renal function, and left ventricular hypertrophy in peritoneal dialysis patients. Serum ADMA measurements and echocardiographic evaluations were performed in 54 peritoneal dialysis patients and 26 healthy volunteers. Residual renal function was measured in peritoneal dialysis patients by urea clearance from a urine collection. Thirty-two of the 54 peritoneal dialysis patients had residual renal function. ADMA levels of the peritoneal dialysis group were found to be significantly higher than those of healthy individuals (p = 0.03). Within the peritoneal dialysis group, ADMA levels of patients with residual renal function were significantly lower than those without residual renal function (p = 0.01), though they were still higher than the ADMA levels of the control group (p=0.04). Serum levels of ADMA were positively correlated with left ventricular mass index (r = 0.29, p = 0.01) and negatively correlated with early mitral inflow velocity (Em) (r = -0.28, p = 0.01), Em/Late mitral inflow velocity (Am) (r = -0,32, p = 0.00), and isovolumetric relaxation time (r = -0.30, p = 0.01). In conclusion, increased ADMA levels seem to be associated with left ventricular hypertrophy in peritoneal dialysis patients, and residual renal function may lead to a reduction of serum ADMA levels.en_US
dc.identifier.citationFatma Ayerden Ebinç, Yasemin Erten, Haksun Ebinç, Hatice Paşaoğlu, Canan Demirtaş, Gülten Taçoy, Rüya Mutluay, Eyüp Koç, Ulver Derici, Kadriye Altok Reis, Musa Bali, Turgay Arınsoy & Şükrü Sindel (2008) The Relationship among Asymmetric Dimethylarginine (ADMA) Levels, Residual Renal Function, and Left Ventricular Hypertrophy in Continuous Ambulatory Peritoneal Dialysis Patients, Renal Failure, 30(4), 401-406.en_US
dc.identifier.doi10.1080/08860220801964285
dc.identifier.endpage406en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue4en_US
dc.identifier.pmid18569913
dc.identifier.scopus2-s2.0-45749103382
dc.identifier.scopusqualityQ2
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org10.1080/08860220801964285
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4293
dc.identifier.volume30en_US
dc.identifier.wosWOS:000256352500009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCAPDen_US
dc.subjectADMAen_US
dc.subjectresidual renal functionen_US
dc.subjectleft ventricular hypertrophyen_US
dc.titleThe relationship among asymmetric dimethylarginine (ADMA) levels, residual renal function, and left ventricular hypertrophy in continuous ambulatory peritoneal dialysis patientsen_US
dc.typeArticle

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