The Effect of Proanthocyanidin on Ischemia-Reperfusion Injury in Skeletal Muscles of Rats

Basit Öğe Kaydı
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.contributor.authorÖzer, Abdullah
dc.contributor.authorKoçak, Başak
dc.contributor.authorSezen, Şaban Cem
dc.contributor.authorArslan, Mustafa
dc.contributor.authorKavutçu, Mustafa
dc.date.accessioned2025-01-21T16:45:19Z
dc.date.available2025-01-21T16:45:19Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and Objectives: Lower limb skeletal muscle ischemia-reperfusion (IR) injury is associated with increased morbidity and mortality, and it is common in several clinical situations such as aortic aneurysms repairment, peripheral arterial surgery, vascular injury repairment, and shock. Although it is generally accepted that oxidative stress mediators have a significant role in IR injury, its precise mechanism is still unknown. Anecdotally, it is sustained not only by structural and functional changes in the organ it affects but also by damage to distant organs. The purpose of this report is to illustrate the effect of proanthocyanidin on IR injury. Materials and Methods: In our study, 18 male Wistar albino rats were used. The subjects were divided into three groups containing six mice each (control, C; ischemia-reperfusion, IR; ischemia-reperfusion and proanthocyanidin; IR-PRO). Intraperitoneal proanthocyanidin was given to the IR and proanthocyanidin groups 30 min before laparotomy, and 1 h ischemia led to these two groups. After one hour, reperfusion started. Muscle atrophy-hypertrophy, muscle degeneration-congestion, fragmentation-hyalinization, muscle oval-central nucleus ratio, leukocyte cell infiltration, catalase enzyme activity, and TBARS were all examined in lower-limb muscle samples after one hour of reperfusion. Results: When skeletal muscle samples were evaluated histopathologically, it was discovered that muscle atrophy-hypertrophy, muscle degeneration-congestion, fragmentation-hyalinization, and leukocyte cell infiltration with oval-central nucleus standardization were significantly higher in the IR group than in the C and IR-P groups. Oval-central nucleus standardization was significantly higher in the IR and IR-PRO groups than in the control group. TBARS levels were significantly higher in the IR group than in the control and IR-PRO groups, while catalase enzyme activity was found to be significantly lower in the IR group than in the control and IR-PRO groups. Conclusions: As a consequence of our research, we discovered that proanthocyanidins administered before IR have a protective impact on skeletal muscle in rats. Further research in this area is required.
dc.description.sponsorshipGazi University
dc.description.sponsorshipThe abstract of this paper was presented at the 18th International Congress of Update in Cardiology and Cardiovascular Surgery as an oral presentation and won a young investigator presentation prize.
dc.identifier.doi10.3390/medicina60050804
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue5
dc.identifier.pmid38792987
dc.identifier.scopus2-s2.0-85194131102
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina60050804
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25611
dc.identifier.volume60
dc.identifier.wosWOS:001231541300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectischemia-reperfusion; proanthocyanidin; lower extremity; rat; TBARS
dc.titleThe Effect of Proanthocyanidin on Ischemia-Reperfusion Injury in Skeletal Muscles of Rats
dc.typeArticle

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