CD44 EXPRESSION IN PROSTATIC ADENOCARCINOMA: CORRELATION WITH GLEASON GRADES
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Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: CD44, a cell-surface adhesion protein, is a marker ofstem cells and is involved in the structural maintenance ofprostate gland basal cells. It plays an important role in prostatecarcinogenesis; however, research results till date have beeninconsistent. The current study was conducted to evaluate theexpression level of CD44 among carcinomas with differentGleason growth patterns and hyperplastic glands.Material and Methods: Eighty archival tissue samples frompatients with either prostate carcinoma of differing Gleasonpatterns or benign prostate hyperplasia from the pathologyarchives of the Kırıkkale University, Faculty of Medicine, from2011 to 2018 were included. Immunoreaction to CD44antibodies was evaluated by calculating positively stained cellpercentage and staining intensity. Mean values and significancewere determined using the Kruskal–Wallis test. p<0.05 wasconsidered significant.Results: CD44 staining was more diffuse and intense in most ofbenign hyperplastic tissues compared to carcinoma cases (pvalues ranged from <0.01 to 0.005). Expression level graduallydecreased with increasing severity of histologic pattern. Pattern3 tumor showed higher percentage of positively stained cellsthan pattern 4 (p<0.01) There was no positivity with CD44 ingrade 5 tumours. Also, in pattern 4 only few cells reacted withCD44. There was no statistically significant difference in thestaining score between pattern 4 and 5 (p=0.278).Conclusion: We conclude that once cancerous properties havebeen established, cells tend to lose the ability of CD44expression. CD 44 expression in low grade carcinomas suggestthat CD 44 maintains the tumor in a differentiated, glandforming state so it may not act as a cancer stem cell marker inprostate carcinogenesis.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp, Onkoloji, Hücre Biyolojisi
Kaynak
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
22
Sayı
2
