CD44 EXPRESSION IN PROSTATIC ADENOCARCINOMA: CORRELATION WITH GLEASON GRADES

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dc.contributor.authorBalcı, Mahi
dc.contributor.authorÖzdemir, Gülhan
dc.date.accessioned2025-01-21T16:17:12Z
dc.date.available2025-01-21T16:17:12Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: CD44, a cell-surface adhesion protein, is a marker ofstem cells and is involved in the structural maintenance ofprostate gland basal cells. It plays an important role in prostatecarcinogenesis; however, research results till date have beeninconsistent. The current study was conducted to evaluate theexpression level of CD44 among carcinomas with differentGleason growth patterns and hyperplastic glands.Material and Methods: Eighty archival tissue samples frompatients with either prostate carcinoma of differing Gleasonpatterns or benign prostate hyperplasia from the pathologyarchives of the Kırıkkale University, Faculty of Medicine, from2011 to 2018 were included. Immunoreaction to CD44antibodies was evaluated by calculating positively stained cellpercentage and staining intensity. Mean values and significancewere determined using the Kruskal–Wallis test. p<0.05 wasconsidered significant.Results: CD44 staining was more diffuse and intense in most ofbenign hyperplastic tissues compared to carcinoma cases (pvalues ranged from <0.01 to 0.005). Expression level graduallydecreased with increasing severity of histologic pattern. Pattern3 tumor showed higher percentage of positively stained cellsthan pattern 4 (p<0.01) There was no positivity with CD44 ingrade 5 tumours. Also, in pattern 4 only few cells reacted withCD44. There was no statistically significant difference in thestaining score between pattern 4 and 5 (p=0.278).Conclusion: We conclude that once cancerous properties havebeen established, cells tend to lose the ability of CD44expression. CD 44 expression in low grade carcinomas suggestthat CD 44 maintains the tumor in a differentiated, glandforming state so it may not act as a cancer stem cell marker inprostate carcinogenesis.
dc.identifier.doi10.24938/kutfd.705435
dc.identifier.endpage239
dc.identifier.issn2148-9645
dc.identifier.issue2
dc.identifier.startpage233
dc.identifier.trdizinid418899
dc.identifier.urihttps://doi.org/10.24938/kutfd.705435
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/418899
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22588
dc.identifier.volume22
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKırıkkale Üniversitesi Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.subjectOnkoloji
dc.subjectHücre Biyolojisi
dc.titleCD44 EXPRESSION IN PROSTATIC ADENOCARCINOMA: CORRELATION WITH GLEASON GRADES
dc.typeArticle

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